Biofilm Phase-2 Advanced: A Key Step to SIBO biofilm support

Biofilm Phase-2 Advanced* is an exclusive formula developed by Dr. Paul S. Anderson, designed to support the disruption of advanced biofilms. Protective structures formed by bacteria in the gastrointestinal tract. This professional-strength formulation, featuring Bismuth Subnitrate, Alpha Lipoic Acid, and Black Cumin Seed (Nigella sativa), is part of Priority One’s advanced nutritional line used by practitioners addressing complex microbial and gut-related conditions.*

Biofilms evolve from early, weaker forms (Phase-1) into stronger, more resilient colonies (Phase-2). These advanced biofilms can act as barriers, shielding harmful bacteria from immune or therapeutic activity. Biofilm Phase-2 Advanced was created to help disrupt these mature biofilms, supporting the body’s natural processes for maintaining microbial balance.*

How It Fits in the SIBO Protocol

Within Dr. Mona Morstein’s SIBO (Small Intestinal Bacterial Overgrowth) Protocol, Biofilm Phase-2 Advanced plays a critical role during the eradication phase—the stage focused on reducing bacterial overgrowth and restoring balance in the small intestine.

SIBO bacteria can form protective biofilms that resist natural antimicrobials and prescription treatments. Biofilm Phase-2 Advanced helps “open up” these protective layers so that antimicrobials—whether herbal (such as berberine or oregano oil) or pharmaceutical—can reach the target microbes more effectively.*

We typically recommend introducing Biofilm Phase-2 Advanced during the active eradication phase:

• Two capsules per day, divided into morning and evening doses.

• Duration: Two weeks when paired with prescription antibiotics, or up to one month when using natural antimicrobials.

• Timing: Best taken on an empty stomach with water, separate from meals or probiotics for optimal activity.*

It is not typically used long-term—only during the active biofilm disruption phase and possibly for a brief period beforehand to help prepare the intestinal environment for eradication.

Ingredient Rationale

Each ingredient in Biofilm Phase-2 Advanced was chosen for its role in supporting biofilm disruption and intestinal balance:

• Bismuth Subnitrate (200 mg) – A mineral complex used in advanced biofilm strategies for its ability to bind to and disrupt biofilm matrices.*

• Alpha Lipoic Acid (300 mg) – A powerful antioxidant and thiol compound that assists in breaking down complex biofilm structures and supports detoxification pathways.*

• Black Cumin Seed (Nigella sativa) (100 mg) – Traditionally used for its broad-spectrum microbial support and antioxidant benefits, helping the body maintain a balanced microbial environment.*

Together, these ingredients target advanced, or “Phase-2,” biofilms that may not respond to enzyme-based (Phase-1) strategies alone.*

Biofilm Phase-2 Advanced™: formulado para la alteración de biopelículas avanzadas.*

$45.00

Un producto exclusivo formulado por: Dr. Paul S. Anderson   El suplemento Biofilm Phase-2 Advanced de Priority One está específicamente formulado como un disruptor avanzado de biopelículas.* Las biopelículas se forman y evolucionan desde formas tempranas (Fase 1 más débil)… read more

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How to Take Biofilm Phase-2 Advanced

• Dosage: 1–2 capsules per day on an empty stomach with a full glass of water.*

• Frequency: Four days weekly or as clinically directed.*

• Duration: Typically 2–4 weeks during the eradication phase, or as advised by your healthcare professional.*

During this time, it is often used alongside antimicrobials such as SIBOtic (Priority One’s botanical antimicrobial formula), ensuring the released bacteria from disrupted biofilms can be properly addressed.*

How It Works in the Body

Biofilm Phase-2 Advanced * is designed to support a balanced intestinal environment by addressing one of the key challenges in maintaining microbial harmony — the presence of mature biofilms.

Biofilms are protective, protein- and polysaccharide-based matrices that bacteria form to shield themselves from environmental stressors. Over time, these structures can become dense and resilient, making it harder for the body’s natural defenses and nutritional interventions to interact with the underlying microbial communities.

Biofilm Phase-2 Advanced * provides nutrients that help the body’s natural processes:

• Bismuth Subnitrate helps to loosen and disperse tightly bound biofilm complexes, creating a more open intestinal environment.*

• Alpha Lipoic Acid supports antioxidant and detoxification pathways that accompany microbial balance, helping maintain the integrity of the intestinal barrier.*

• Black Cumin Seed (Nigella sativa) contributes broad nutritional support for a healthy immune and microbial response within the gut ecosystem.*

By promoting the natural breakdown of dense, mature biofilms, the formula helps “open up” the intestinal environment so that other supportive measures—such as herbal or prescription antimicrobials—can interact with the exposed microbes more effectively.* This process represents what Dr. Paul S. Anderson describes as a Phase-2 biofilm strategy, implemented after initial, enzyme-based “Phase-1” methods have achieved their foundational work.

Dr. Anderson’s Clinical Philosophy

Dr. Anderson’s phased approach to biofilm management focuses on precision, timing, and recovery support to help practitioners optimize each step of a complex protocol. His recommendations emphasize:

1. Pausing Phase-1 agents (such as enzyme or essential-oil blends) while using Phase-2 Advanced to avoid overlapping mechanisms and ensure targeted focus.*

2. Transitioning back to Phase-1 support after completing the Phase-2 period, maintaining microbial balance during the recovery or maintenance phase.*

3. Adjusting frequency—often using Biofilm Phase-2 Advanced 2 to 4 days per week after the initial cycle—to provide continued nutritional support in complex or long-term cases.*

This progressive method recognizes that gut balance is dynamic. By alternating and sequencing supportive formulas, practitioners can better align nutritional strategies with the body’s natural cycles of disruption, clearance, and restoration.*

Common Questions

1. Can Biofilm Phase-2 Advanced be taken with other antimicrobials?

Yes. It is typically combined with either herbal or prescription antimicrobials during the eradication phase. However, it should be introduced under practitioner guidance to ensure timing and tolerance are optimized.*

2. What if I experience a “flare” or aggravation?

Temporary symptoms can occur when the immune system reacts to the release of bacteria from disrupted biofilms. Dr. Anderson notes that such responses are normal and may be managed by:

• Supporting adrenal and thyroid function.

• Reducing Biofilm Phase-2 frequency temporarily (e.g., once weekly until symptoms settle).

• Continuing antimicrobial support as tolerated.*

3. Should Biofilm Phase-2 Advanced be used at the start of SIBO treatment?

Not always. For patients with complex or long-standing illness, foundational support—such as gut healing, adrenal, liver, and immune support—should come first. Once the body is stronger, Biofilm Phase-2 Advanced may be introduced to open biofilms and improve treatment efficacy.*

Integrating with the Complete SIBO Protocol

Priority One’s SIBO Protocol offers a comprehensive four-part system:

1. SIBOtic – Herbal antimicrobial support.*

2. Biofilm Phase-2 Advanced – Advanced biofilm disruption.*

3. SIBO-MMC – Natural prokinetic support to promote healthy gut motility.*

4. SIBO Rebuild – Post-treatment support for gut lining and nervous system recovery.*

When used in combination under clinical supervision, this system helps support each stage of the SIBO healing journey—from eradication through restoration.*

Learn more about the overall Sibo Protocol here. 

Summary

Biofilm Phase-2 Advanced* is a practitioner-formulated tool for supporting the disruption of mature biofilms during SIBO and other complex microbial protocols. Designed by Dr. Paul S. Anderson and integrated into Dr. Mona Morstein’s clinical SIBO protocol, it plays a vital role in helping antimicrobials work more effectively while supporting gut balance.*

References: Available upon request

• Dr. Mona Morstein, SIBO Information and Treatment Protocol

  Dr. Mona Morstein SIBO protocol

• Dr. Paul S. Anderson, Phase-2 Biofilm Q&A

  Biofilm-Phase-2-QnA (1) (1)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.