Priority Folate — Optifolin+™ Active L-Methylfolate for Precision Methylation, Homocysteine Support & Cellular Health
Priority Folate is a precision single-ingredient folate supplement delivering Optifolin+™ — one of the most bioavailable and stable forms of active L-methylfolate commercially available — at 1,000mcg DFE (588mcg folate) per capsule. Available in 30 and 60 capsule sizes, one capsule per day.*
What's inside and why it matters
Folate as Optifolin+™ (6S)-5-Methyltetrahydrofolate, Choline Salt (1,000mcg DFE / 588mcg Folate, 250% DV)
Optifolin+™ is a registered trademark of Balchem Corporation, delivering (6S)-5-methyltetrahydrofolic acid as the choline salt — a patented formulation that provides the most bioavailable and shelf-stable form of L-methylfolate available.*
The folate-MTHFR problem — Most folate supplements use folic acid — the synthetic, fully oxidised form that must undergo several enzymatic conversion steps before it can participate in the methylation cycle. The critical enzyme in this conversion pathway is MTHFR (methylenetetrahydrofolate reductase). Up to 40% of the population carries MTHFR polymorphisms that reduce this enzyme's activity by 30–70% — meaning folic acid supplementation may be largely ineffective for a significant proportion of people.*
Optifolin+™ bypasses MTHFR entirely — providing (6S)-5-methyltetrahydrofolic acid — the biologically active form that enters the methylation cycle directly as the methyl donor for the methionine synthase reaction. This makes Priority Folate effective for supporting normal folate status and methylation regardless of MTHFR genetic status.*
Why the choline salt form? Optifolin+™ uses the choline salt — a form developed by Balchem Corporation for superior stability and hygroscopic properties, maintaining potency better during storage. The choline component also provides a small contribution of choline — an important methyl donor and membrane phospholipid precursor.*
Normal methylation cycle function — (6S)-5-methyltetrahydrofolate is the primary methyl donor for the methionine synthase reaction — the enzyme that converts homocysteine back to methionine. Methionine is then converted to SAMe (S-adenosylmethionine) — the body's universal methyl donor that methylates DNA, RNA, proteins, neurotransmitters, and hundreds of other molecules.*
Normal homocysteine metabolism — By supporting the remethylation of homocysteine to methionine, methylfolate directly supports normal homocysteine clearance — one of the primary nutritional strategies for maintaining normal homocysteine levels.*
Normal DNA synthesis and cellular division — Folate is an essential cofactor for thymidylate synthase — the enzyme that synthesises the DNA base thymidine. Every rapidly dividing cell in the body has a high folate requirement for normal DNA synthesis. The active methylfolate form in Optifolin+™ is directly available for this purpose.*
Normal neurotransmitter synthesis — Methylfolate supports normal serotonin, dopamine, and norepinephrine synthesis via its role in BH4 (tetrahydrobiopterin) cofactor regeneration — the essential cofactor for the aromatic amino acid hydroxylases that produce these neurotransmitters.*
Pregnancy folate support — Adequate folate is essential in the periconceptional period and early pregnancy for normal fetal neural tube development. Active methylfolate from Optifolin+™ bypasses MTHFR, providing reliable folate support for this critical developmental window.*
At a glance — what this formula supports
- Normal methylation cycle function via Optifolin+™ active L-methylfolate*
- Normal homocysteine clearance via remethylation to methionine*
- MTHFR bypass — effective regardless of MTHFR genetic polymorphism status*
- Normal DNA synthesis and cellular division in high-turnover tissues*
- Normal neurotransmitter synthesis via BH4 regeneration support*
- Normal cognitive function and mood balance via methylation-dependent pathways*
Quality you can verify
Every batch of Priority Folate is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Features Optifolin+™ — a registered trademark form of active L-methylfolate from Balchem Corporation.
Available in 30 and 60 vegetarian capsule sizes.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, consult your physician before using this product — contains active folate which is particularly important during pregnancy. If you are taking medications including methotrexate or other antifolates, consult your healthcare provider before use.
