Tributyrin Advanced | CoreBiome® Tributyrin, BeautyOLIGO® GOS & ImmunoLin® Immunoglobulin for Gut Barrier & Microbiome Support by Dr. Morstein | 120 Capsules

Tributyrin Advanced — CoreBiome® Tributyrin, BeautyOLIGO® Galacto-Oligosaccharides & ImmunoLin® Immunoglobulin for Gut Barrier, Microbiome & Mucosal Immune Support by Dr. Morstein

Tributyrin Advanced is Dr. Mona Morstein ND's premium three-ingredient gut health formula — combining three of the most clinically advanced, patented branded ingredients available for intestinal barrier support, prebiotic microbiome nutrition, and mucosal immune defence. Rather than a broad multi-ingredient formula, Tributyrin Advanced is built around three high-dose, evidence-backed compounds each targeting a distinct and critical dimension of gut health.*

Serving size is 4 vegetarian capsules, 30 servings per container (120 capsules).

What's inside and why it matters

CoreBiome® Tributyrin 55% (545mg yielding 300mg active Tributyrin per serving)

CoreBiome® is a registered trademark of Compound Solutions, Inc. — a leading US nutraceutical ingredient company. CoreBiome® provides tributyrin — a triglyceride ester consisting of three butyric acid (butyrate) molecules bound to a glycerol backbone — at 55% concentration, yielding 300mg of active tributyrin per serving.*

Why tributyrin rather than butyrate salts? Standard butyrate supplements are typically provided as butyrate salts (sodium butyrate, calcium/magnesium butyrate, or beta-hydroxybutyrate). These salts are water-soluble and are rapidly absorbed in the stomach and upper small intestine — meaning much of the butyrate never reaches the colonocytes (colon-lining cells) and lower intestinal mucosa where it is most needed.*

Tributyrin is a lipid-based (fat-soluble) form of butyrate. Because it is a triglyceride, tributyrin is not absorbed in the stomach — instead, it passes intact through the stomach and upper digestive tract, where pancreatic lipase gradually cleaves the butyrate molecules from the glycerol backbone throughout the small and large intestine. This provides sustained, targeted butyrate delivery to the entire intestinal length — particularly the colon — where butyrate has its most important physiological effects.*

Why butyrate matters — Butyrate (butyric acid, C4:0) is a short-chain fatty acid (SCFA) produced by colonic bacterial fermentation of dietary fibre. It is the primary energy source for colonocytes — providing approximately 70% of colonocyte energy needs. Beyond energy supply, butyrate is one of the most important regulators of intestinal health known:

It supports normal tight junction protein expression (claudins, occludin, ZO-1) — directly strengthening the physical intestinal barrier. It supports normal histone deacetylase (HDAC) inhibition in intestinal epithelial cells — modulating normal gene expression for barrier maintenance and healthy inflammatory balance. It supports normal T-regulatory (Treg) cell differentiation in the intestinal lamina propria — promoting normal mucosal immune tolerance. And it provides anti-inflammatory signalling via its activity at free fatty acid receptors (GPR109A, GPR43) on intestinal epithelial cells.*

At 300mg of active tributyrin per serving — delivered via CoreBiome®'s lipid-based protective form — Tributyrin Advanced provides a meaningful, bioavailable butyrate dose to the intestinal mucosa where it matters most.*

BeautyOLIGO® Galacto-Oligosaccharide (500mg per serving)

BeautyOLIGO® is a registered trademark of New Cremar Co., Ltd — a leading European prebiotic ingredient company — providing galacto-oligosaccharides (GOS) at 500mg per serving. Galacto-oligosaccharides are prebiotic fibres synthesised from lactose via enzymatic transglycosylation, producing short-chain galactose-containing oligosaccharides structurally similar to human milk oligosaccharides (HMOs).*

GOS are among the most extensively researched prebiotic fibres in clinical nutrition. As prebiotics, GOS are selectively fermented by beneficial colonic bacteria — particularly Bifidobacterium and Lactobacillus species — supporting their growth and competitive advantage over less beneficial organisms in the gut microbiome.*

The microbial fermentation of GOS by Bifidobacterium produces additional butyrate and other SCFAs, creating a synergistic relationship with the CoreBiome® tributyrin in this formula: BeautyOLIGO® feeds the bacteria that produce endogenous butyrate, while CoreBiome® delivers exogenous butyrate directly to the colonocytes. Together, they support butyrate availability in the colon through two complementary pathways.*

GOS also directly support normal intestinal mucus layer thickness, normal goblet cell function (mucin production), and normal intestinal immune cell populations — including Treg cells that maintain mucosal immune tolerance.*

ImmunoLin® Immunoglobulin Protein Isolate (1,000mg per serving)

ImmunoLin® is a registered trademark of PROLIANT BIOLOGICALS, LLC — a leading US manufacturer of bovine serum-derived immunoglobulin concentrates. ImmunoLin® provides a purified bovine immunoglobulin protein isolate at 1,000mg per serving — the highest-dosed ingredient in this formula.*

ImmunoLin® provides concentrated immunoglobulins — primarily IgG (immunoglobulin G) — from bovine serum. Serum-derived immunoglobulins are distinct from colostrum-derived immunoglobulins in their higher IgG purity and concentration. When taken orally, immunoglobulins provide direct mucosal immune support by binding and neutralising gut pathogens, antigens, and endotoxins (lipopolysaccharide, LPS) in the intestinal lumen before they can cross the gut barrier and trigger systemic immune responses.*

Immunoglobulins and gut barrier protection — One of the most significant contributors to intestinal barrier disruption is LPS — the outer membrane component of gram-negative bacteria. When gut permeability is increased ("leaky gut"), LPS translocates across the barrier into the portal circulation, triggering systemic low-grade inflammatory activation (metabolic endotoxaemia). ImmunoLin®'s concentrated IgG directly binds LPS in the intestinal lumen, supporting normal LPS neutralisation before barrier translocation can occur — protecting the intestinal barrier at its most vulnerable point.*

At 1,000mg per serving — a high clinical dose of immunoglobulin protein isolate — ImmunoLin® provides a meaningful mucosal immunoglobulin concentration for intestinal immune support.*

The three-component gut health strategy

Tributyrin Advanced addresses intestinal health through three synergistic and complementary mechanisms:

Barrier nutrition (CoreBiome® tributyrin) — providing the primary energy substrate and barrier-regulatory short-chain fatty acid directly to colonocytes.*

Microbiome support (BeautyOLIGO® GOS) — selectively feeding beneficial Bifidobacterium and Lactobacillus, supporting the microbial production of additional endogenous butyrate and maintaining a healthy microbiome composition.*

Mucosal immune protection (ImmunoLin® immunoglobulin) — providing concentrated IgG for direct luminal binding of pathogens and LPS, supporting normal mucosal immune defence and barrier protection from the luminal side.*

At a glance — what this formula supports

• Normal intestinal barrier integrity via CoreBiome® tributyrin butyrate delivery to colonocytes*
• Normal tight junction protein expression and gut permeability support via butyrate*
• Normal microbiome composition via BeautyOLIGO® prebiotic GOS fermentation support*
• Normal endogenous butyrate production via prebiotic microbiome support*
• Normal mucosal immune defence and LPS neutralisation via ImmunoLin® IgG*
• Comprehensive gut barrier, microbiome & mucosal immune support in a single formula*

Quality you can verify

Every batch of Tributyrin Advanced is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Features CoreBiome® (Compound Solutions, Inc.), BeautyOLIGO® (New Cremar Co., Ltd), and ImmunoLin® (PROLIANT BIOLOGICALS, LLC) — three registered trademark branded ingredients. Developed exclusively by Dr. Mona Morstein ND.

120 vegetarian capsules per bottle (30 servings).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warnings

WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. ImmunoLin® is derived from bovine serum — if you have a known beef or bovine protein allergy, consult your healthcare provider before use. If you have a medical condition or are taking medications, consult your healthcare provider before use.