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The Hidden Connection Between Gut and Mind
Feeling foggy, anxious, or low in energy might have more to do with your gut than you think. Emerging research continues to reveal that the digestive system and the brain are in constant communication through a network known as the gut-brain axis.
This intricate system connects the emotional and cognitive centers of your brain to your intestinal environment, influencing everything from mood and focus to stress resilience and energy levels.*
At Priority One Vitamins, we understand that gut health is foundational to overall wellness. Our doctor-formulated digestive and cognitive support lines were developed to help nurture the gut-brain relationship—supporting clear thinking, calm focus, and balanced emotional well-being.*
Understanding the Gut-Brain Axis
The gut-brain axis is the two-way communication pathway between your central nervous system and your enteric nervous system (the “second brain” in your digestive tract). This relationship is mediated by the vagus nerve, immune signaling, and the gut microbiome—the trillions of microorganisms living in your intestines.
Up to 90% of serotonin, a neurotransmitter that supports mood and emotional balance, is produced in the gut.* Likewise, gut bacteria play a role in producing or influencing other neurochemicals such as dopamine, GABA, and acetylcholine—all essential for focus, relaxation, and cognitive performance.*
When the microbiome is balanced, communication between the gut and brain functions smoothly. But when it’s disrupted—by poor diet, stress, illness, or bacterial overgrowth—this connection can weaken, leading to symptoms like:
Brain fog and lack of concentration
Mood swings or irritability
Sleep disruption
Digestive discomfort (bloating, irregularity)
Fatigue and low motivation
This is where supporting gut integrity and microbial balance becomes key to maintaining mental clarity and emotional steadiness.*
How Gut Imbalance Affects Mood and Focus
When digestion is compromised, nutrients aren’t absorbed as efficiently. Inflammation and microbiome imbalances can affect how neurotransmitters are produced and transmitted between the gut-brain axis.*
Conditions like Small Intestinal Bacterial Overgrowth (SIBO) can interfere with nutrient absorption and create a buildup of gases and toxins that influence brain function. This is why people struggling with gut imbalances often report not just digestive distress—but also mental fatigue and difficulty focusing.*
Priority One’s SIBO Protocol—featuring SIBOtic, SIBO-MMC, and SIBO Rebuild—was developed to help restore microbial balance, motility, and gut lining integrity. These formulations work synergistically to support digestion, balance the microbiome, and rebuild the intestinal environment for optimal absorption and brain-gut communication.*
Read more about how our Sibo Protocol works in the following blog posts
Biofilm Phase 2- Advanced A Key step in the Sibo Protocol
Nourishing the Gut-Brain Connection Naturally*
The good news is that you can support your gut-brain axis through targeted nutrition and supplementation. The following key nutrients and formulas can help promote clarity, calm, and digestive balance from within.*
1. Probiotic Blend 50 Billion CFU— Restoring Microbial Harmony
Probiotic Blend (30 Capsules) - 50 Billion CFU Probiotic Flora for Digestive and Immune Health*
$39.50
Probiotic Blend – 50 Billion CFU Probiotic Flora for Digestive and Immune Health* (30 Capsules) Probiotic Blend delivers advanced microbiome support with 50 billion CFU from seven clinically studied probiotic strains, combined with prebiotic inulin (FOS) for enhanced gut balance… read more
A balanced microbiome is essential for mental and emotional health. Probiotic blend 50 billion cfu provides multiple strains of beneficial bacteria, including Lactobacillus and Bifidobacterium, to support digestive balance and healthy communication between the gut and brain.*
Research shows that certain probiotics—often called psychobiotics—may help influence neurotransmitter production and stress resilience by interacting with the vagus nerve and central nervous system.*
By replenishing friendly bacteria, Probiotic blend 50 Billion CFU helps maintain the delicate ecosystem that affects both digestion and emotional well-being.*
2. Pre + Probiotic Support — Feeding Your Gut Flora
Pre+Probiotic (120 Vegetarian Capsules) Pre+Probiotic support healthy gut microflora.*
$41.00
Pre+Probiotic – Advanced Gut Microbiome and Digestive Support* Pre+Probiotic is a scientifically formulated combination of PreticX™ XOS prebiotic fiber and LactoSpore® Bacillus coagulans probiotic, designed to support a balanced intestinal environment and promote overall digestive and immune wellness.* This synergistic… read more
Probiotics thrive when they have nourishment—and that’s where prebiotics come in. These indigestible fibers act as food for beneficial bacteria, helping them multiply and colonize the intestines.*
Priority One’s Pre+ Probiotic support formulas provide the nutrients your gut flora need to flourish, promoting microbial diversity and the production of short-chain fatty acids that benefit brain function.*
This one-two combination of Prebiotic + Probiotic creates a balanced environment for mental clarity, focus, and a more stable mood.*
3. Digestive Enzymes — Supporting Nutrient Absorption
Shop Digestive Enzyme Formulas
Even with a balanced microbiome, nutrient absorption depends on proper digestion and healthy digestion supports focus. Digestive enzymes help break down proteins, fats, and carbohydrates into usable components that feed your cells—including your brain cells.*
By improving absorption, enzyme supplementation ensures that your body gets the vitamins, minerals, and amino acids it needs for neurotransmitter synthesis and overall cognitive performance.* We proudly supply various digestive enzyme formulas to meet your individual needs, from high potency to mid range along with both vegan and non vegan sources.
4. SIBO-MMC and SIBO Rebuild — Advanced Gut Restoration
Shop SIBO-MMC | Shop SIBO Rebuild
For those needing additional gut support, SIBO-MMC helps maintain healthy intestinal motility and prevent stagnation of the small intestine.* This supports the natural cleansing waves that keep bacterial balance in check.
SIBO Rebuild provides nutrients that help nourish the gut lining and promote repair after microbial imbalance—helping strengthen the intestinal barrier that influences both digestion and brain function.*
Together, these professional-grade formulations work to restore balance from within, supporting clearer thinking, consistent energy, and a more resilient mood.*
Lifestyle Habits That Support the Gut-Brain Axis
Nutrition and supplementation work best when paired with daily habits that reinforce balance. To help your gut microbiome balance and brain function in harmony:
Manage stress: Chronic stress alters gut flora and digestion. Try breathwork, meditation, or light exercise to calm the nervous system.
Eat whole foods: A diet rich in fiber, antioxidants, and omega-3s supports microbial and brain health.
Prioritize sleep: Gut bacteria follow circadian rhythms—consistent sleep helps regulate mood and metabolism.
Stay hydrated: Adequate water intake helps with digestion, detoxification, and neurotransmitter transport.
These habits, combined with targeted nutritional support, create a foundation for lasting gut-brain axis wellness.*
The Priority One Difference
At Priority One Vitamins, our supplements are developed with clinical precision and manufactured in our NSF CGMP-certified facility in the Pacific Northwest. Each formula is created with high-quality ingredients, tested for purity, and trusted by healthcare professionals nationwide.
Our gut health line—including Probiotic Formula, Prebiotic Support, Digestive Enzymes, and the SIBO Protocol—reflects our commitment to integrity, transparency, and practitioner-grade quality that supports the body’s natural balance from within.*
FDA Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FAQs
1. What is the gut-brain connection?
It’s the communication network linking your digestive system and brain through nerves, hormones, and the microbiome—helping regulate mood, focus, and emotional balance.*
2. Can probiotics really affect mood?
Yes. Certain probiotic strains produce or influence neurotransmitters like serotonin and GABA, which play roles in calmness, motivation, and clarity.*
3. What’s the difference between probiotics and prebiotics?
Probiotics are beneficial bacteria; prebiotics are the fibers that feed them. Together, they help maintain a balanced gut ecosystem that supports both digestion and mental well-being.*
4. How does SIBO affect brain function?
SIBO can disrupt nutrient absorption and produce byproducts that influence mood, focus, and energy. Supporting microbial balance may help restore clarity and calm.*
5. Are Priority One’s gut health supplements practitioner-grade?
Yes. All formulas are developed and produced in-house in our NSF CGMP-certified facility, ensuring potency, purity, and professional-grade quality you can trust.*
