R.E.M.™ — Melatonin, 5-HTP, GABA, L-Theanine, Jujube & Multi-Mechanism Support for Normal Sleep Cycles & Restorative Rest
R.E.M.™ is a comprehensive sleep support formula combining a multi-mechanism approach to normal sleep initiation, sleep cycle regulation, and restorative rest. Rather than relying on a single high-dose sedative compound, R.E.M.™ brings together seventeen complementary ingredients that address the neurochemical, hormonal, and physiological dimensions of normal healthy sleep.*
Please note: Contains soy (phosphatidylserine).
Serving size is 1 vegetarian capsule, 30 servings per container.
What's inside and why it matters
Vitamin B6 as Pyridoxine HCl (4mg, 200% DV) — An essential cofactor for the conversion of L-tryptophan to serotonin and then to melatonin. Adequate B6 is required for normal endogenous melatonin synthesis and healthy serotonin production.*
Vitamin B12 as Cyanocobalamin (100mcg, 1,667% DV) — B12 is involved in melatonin synthesis regulation and plays a role in maintaining normal circadian rhythm synchronisation, supporting normal neurological function and healthy sleep-wake cycle signalling.*
Pantothenic Acid as d-Pantothenate (20mg, 200% DV) — Supporting normal adrenal hormone metabolism and healthy stress response — both of which directly influence sleep quality.*
Calcium as Aspartate Rice Chelate Carbonate (50mg, 5% DV) — Calcium is involved in normal tryptophan conversion to serotonin and in normal REM sleep regulation.*
Magnesium as Magnesium Malate Oxide (11.5mg, 3% DV) — Supporting normal GABA receptor sensitivity — directly relevant to sleep given GABA's central role in sleep initiation — and normal muscle relaxation.*
L-Glutathione (3mg) — Supporting normal antioxidant defence during sleep — the period when cellular repair and antioxidant regeneration is most active.*
Hops Strobile Extract 4:1 (Humulus lupulus, 4mg per capsule) — A 4:1 concentrated extract of hops strobile. Hops' primary sedative constituent supports normal GABA receptor activity, and hops has a centuries-long tradition in European herbal medicine as a nervine sedative.*
Lemon Balm Whole Herb Extract 4:1 (Melissa officinalis, 5mg per capsule) — A 4:1 concentrated lemon balm extract supporting normal GABA-T (GABA transaminase) inhibition — reducing GABA breakdown — and normal adenosine receptor activity, contributing to normal sleep initiation and healthy nervous system calm.*
Melatonin (1mg per capsule) — At 1mg, R.E.M.™ uses the lowest and most physiologically appropriate dose of melatonin for sleep support. This dose is closest to the body's normal nocturnal melatonin output — supporting normal sleep-wake cycle signalling without the morning grogginess or endocrine suppression associated with high-dose melatonin.*
Inositol (10mg) — Supporting normal serotonin receptor sensitivity and healthy cellular signalling in neurological pathways involved in sleep and mood regulation.*
L-5-Hydroxytryptophan 98% from Griffonia simplicifolia seed (30mg per capsule) — The highest-dosed ingredient in this formula. 5-HTP is the immediate precursor to serotonin — one step closer to serotonin than L-tryptophan — and the most direct nutritional pathway to supporting normal endogenous serotonin production. Serotonin is then converted to melatonin in the pineal gland during darkness, making 5-HTP doubly relevant to sleep. At 98% purity from Griffonia simplicifolia seed — the richest plant source of 5-HTP — and 30mg per capsule, this provides a well-tolerated, clinically studied dose.*
Peppermint Leaf Extract 4:1 (Mentha × piperita, 20mg per capsule) — A 4:1 concentrated extract providing compounds that support normal smooth muscle relaxation, healthy nervous system calm, and normal digestive comfort — the latter being relevant given that GI discomfort is a common sleep disruptor.*
Jujube Seed Extract 2% Jujuboside (Ziziphus jujuba, 10mg per capsule) — Standardised to 2% jujuboside — the primary bioactive saponin of jujube seed. Ziziphus jujuba seed (Suan Zao Ren) is one of the primary herbs in traditional Chinese medicine for supporting normal sleep and healthy nervous system calm. Jujubosides support normal GABA-A receptor activity and have been studied for their role in supporting normal sleep architecture.*
L-Theanine (10mg per capsule) — The amino acid from green tea that promotes alpha brain wave activity — the neural pattern associated with relaxed, calm alertness. L-Theanine supports normal GABA and serotonin activity and promotes a relaxed mental state, supporting normal sleep onset quality when taken at bedtime.*
DGL Deglycyrrhizinated Licorice Root (Glycyrrhiza glabra, 6mg per capsule) — Included for its adrenal-supportive and normal cortisol-regulating properties. Since elevated evening cortisol is one of the primary causes of sleep onset difficulty, DGL's support for normal HPA axis function and healthy cortisol balance is a targeted inclusion in a sleep formula.*
GABA (gamma-aminobutyric acid, 50mg per capsule) — The primary inhibitory neurotransmitter of the central nervous system — the brain's natural "off switch" that quiets excessive neural firing and supports normal sleep initiation. At 50mg, GABA provides nutritional support for normal inhibitory neurotransmitter activity in the brain's sleep-promoting circuits.*
DMG (Dimethylglycine HCl, 50mg per capsule) — N,N-dimethylglycine supports normal neurotransmitter methylation reactions, normal energy metabolism, and normal immune function — used in orthomolecular medicine for its neurological and supportive properties.*
MSM (Methylsulfonylmethane, 20mg per capsule) — A naturally occurring organic sulphur compound supporting normal joint and tissue comfort (reducing physical discomfort that can disrupt sleep), normal antioxidant defence, and healthy inflammatory balance.*
Phosphatidylserine 20% (10mg per capsule) — A phospholipid component of neuronal cell membranes specifically studied for its role in supporting normal HPA axis function and healthy cortisol regulation — including normalising elevated evening cortisol, one of the most common biochemical drivers of sleep onset difficulty. Contains soy.*
At a glance — what this formula supports
- Normal sleep initiation via Melatonin 1mg & GABA 50mg*
- Normal serotonin and melatonin production via 5-HTP 98% 30mg & B6*
- Normal sleep quality and healthy sleep architecture via Jujube 2% jujuboside*
- Normal evening cortisol balance via Phosphatidylserine & DGL*
- Relaxed nervous system state and normal alpha brain wave activity via L-Theanine*
- GABAergic nervous system calm via Hops, Lemon Balm & GABA*
Quality you can verify
Every batch of R.E.M.™ is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Contains soy (phosphatidylserine).
30 vegetarian capsules per bottle.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. Contains soy. Do not use with prescription sleep medications without consulting your healthcare provider. Do not drive or operate heavy machinery after use. If you have a depressive condition or are taking antidepressants (particularly MAOIs or SSRIs), consult your healthcare provider before use — contains 5-HTP.
