How to Take the SIBO Protocol: A Step-by-Step Guide to Eradication, Protection, and Gut Healing

How to Take the SIBO Protocol: A Step-by-Step Guide to Eradication, Protection, and Gut Healing


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A Step-by-Step Guide to Eradication, Protection, and Gut Healing

Small Intestinal Bacterial Overgrowth (SIBO) is a condition that affects thousands of people, disrupting digestion and causing persistent bloating, discomfort, and fatigue. At Priority One Vitamins, our SIBO Protocol was developed by leading functional medicine experts to help restore balance to the gut through a structured, multi-phase approach that supports every stage of recovery — from eradication to rebuilding.

Formulated by Dr. Mona Morstein, a pioneer in naturopathic gastrointestinal health, and Dr. Paul Anderson, an authority in integrative medicine, this protocol combines clinical insight with practitioner-grade formulations designed to help you feel your best again.


Understanding SIBO

SIBO occurs when bacteria that normally live in the large intestine migrate into the small intestine. This imbalance can interfere with digestion and absorption, leading to symptoms such as bloating, gas, abdominal pain, food sensitivities, and nutrient deficiencies.

Treating SIBO effectively requires more than simply reducing bacterial overgrowth. A long-term solution involves supporting digestion, motility, and the integrity of the intestinal lining — all of which are covered by the Priority One SIBO Protocol.


The Doctor-Formulated Four-Phase SIBO Protocol

This system was carefully designed by Dr. Mona Morstein to target the root causes of SIBO and to support healing at every stage of the process. Each phase plays a vital role in restoring gut balance and long-term wellness.


Phase 1 – Eradication (Sibotic) 

SIBOtic- Ingredientes que equilibran las bacterias*

SIBOtic- Ingredientes que equilibran las bacterias*

$85.00

SIBOtic es una formulación única de la Dra. Mona Morstein que contiene una colección completa y dosificada terapéuticamente de ingredientes que equilibran las bacterias en un solo producto. Diseñado para pacientes que prefieren una alternativa botánica de alta potencia. Paso… read more

The first step focuses on rebalancing the microbiome and reducing the bacterial overgrowth that contributes to SIBO.

Sibotic, formulated by Dr. Mona Morstein, combines targeted botanical ingredients and nutrients that support the body’s natural cleansing processes and microbial balance.

This phase helps clear the way for better digestion and prepares the gut for repair and recovery.

Shop Sibotic now to begin your eradication phase.


Phase 2 – Motility Support (SIBO-MMC) 

SIBO-MMC: botánicos y nutrientes diseñados para ayudar a maximizar el funcionamiento saludable de los nervios del complejo motor migratorio (MMC). *

SIBO-MMC: botánicos y nutrientes diseñados para ayudar a maximizar el funcionamiento saludable de los nervios del complejo motor migratorio (MMC). *

$60.00

Mejore su salud intestinal con el suplemento especialmente diseñado por la Dra. Mona Morstein. Repleta de poderosos ingredientes botánicos y nutrientes, esta fórmula respalda el funcionamiento óptimo de los nervios del complejo motor migratorio (MMC). Experimente un proceso de digestión… read more

Once the overgrowth is under control, it’s essential to help the digestive system maintain normal movement through the Migrating Motor Complex (MMC). When the MMC functions properly, food and bacteria are moved efficiently through the small intestine, helping prevent relapse.

SIBO-MMC, created by Dr. Mona Morstein, is designed to encourage healthy motility and support long-term digestive comfort.

This phase helps ensure that bacteria do not build up again after treatment.

Shop SIBO-MMC today to support healthy gut movement and maintain progress.


Phase 3 – Protection and Rebuilding (SIBO Rebuild)

SIBO-Rebuild: apoya la salud de los nervios y del revestimiento intestinal.*

SIBO-Rebuild: apoya la salud de los nervios y del revestimiento intestinal.*

$65.00

Esta formulación especializada de la Dra. Mona Morstein está diseñada para apoyar la salud de los nervios y el revestimiento intestinal.* SIBO-Rebuild TM proporciona elementos para respaldar la capacidad natural del cuerpo para regenerar los nervios del complejo motor migratorio… read more

After addressing the overgrowth and restoring motility, it’s time to strengthen and nourish the intestinal lining.

SIBO Rebuild, also formulated by Dr. Mona Morstein, provides nutrients and botanicals that support the gut barrier and promote repair. It’s a crucial step for nutrient absorption, immune balance, and ongoing digestive wellness.

This phase helps fortify the digestive system and maintain long-term results.

Shop SIBO Rebuild now to promote gut repair and lasting resilience.


Phase 4 – Digestive Support (SIBOZyme and SIBOZyme no HCL)

SIBOZyme No HCL (180 cápsulas vegetarianas) Respalda una digestión saludable en pacientes que buscan el equilibrio bacteriano del intestino delgado.* - Formulación exclusiva de la Dra. Mona Morstein

SIBOZyme No HCL (180 cápsulas vegetarianas) Respalda una digestión saludable en pacientes que buscan el equilibrio bacteriano del intestino delgado.* - Formulación exclusiva de la Dra. Mona Morstein

$100.00

Por pedido hemos agregado enzimas digestivas SIBOZyme sin HCL a nuestra línea de productos exclusivos formulados por la Dra. Mona Morstein. Formulado para apoyar una digestión saludable en pacientes que buscan un equilibrio bacteriano en el intestino delgado.* Un revestimiento… read more

SIBOZyme: apoya la digestión saludable en pacientes que buscan el equilibrio bacteriano del intestino delgado.* - Formulación exclusiva de la Dra. Mona Morstein

SIBOZyme: apoya la digestión saludable en pacientes que buscan el equilibrio bacteriano del intestino delgado.* - Formulación exclusiva de la Dra. Mona Morstein

$100.00

Mejore la digestión y equilibre la salud intestinal con soporte bacteriano del intestino delgado. Paso 2: Una dosis típica sugerida por el Dr. Morstein es de 1 a 2 cápsulas con las comidas, 3 veces al día. Ingredientes Clorhidrato de… read more

Digestive enzyme activity can be impaired during and after SIBO recovery, leading to lingering discomfort or bloating after meals.

SIBOZyme and SIBOZyme no HCL, both created by Dr. Mona Morstein, provide comprehensive enzyme support to help the body break down food efficiently and absorb nutrients.

These formulas can be used throughout all stages of the protocol to promote smooth digestion and comfort after eating. Some individuals with Sibo react better to the formula without HCL. 

Shop SIBOZyme or SIBOZyme no HCL to enhance digestive performance and daily comfort.


For Stubborn or Recurrent Cases (Biofilm Phase 2 Advanced)

Biofilm Phase-2 Advanced™: formulado para la alteración de biopelículas avanzadas.*

Biofilm Phase-2 Advanced™: formulado para la alteración de biopelículas avanzadas.*

$45.00

Un producto exclusivo formulado por: Dr. Paul S. Anderson   El suplemento Biofilm Phase-2 Advanced de Priority One está específicamente formulado como un disruptor avanzado de biopelículas.* Las biopelículas se forman y evolucionan desde formas tempranas (Fase 1 más débil)… read more

Some individuals experience persistent SIBO because bacteria form protective layers called biofilms. These biofilms can make it harder to reach and address the imbalance effectively.

Biofilm Phase 2 Advanced, developed by Dr. Paul Anderson, contains specialized enzymes and compounds designed to help disrupt these biofilms, allowing other supplements in the protocol to work more efficiently.

For difficult or recurring cases, this formula can be used alongside the eradication phase under practitioner guidance.

Shop Biofilm Phase 2 Advanced to strengthen your SIBO support plan.


Supporting Gut Recovery Naturally

In addition to following the SIBO Protocol, lifestyle and dietary habits play a key role in lasting results. Consider these supportive strategies:

  • Eat balanced meals and allow several hours between them to promote gut motility.

  • Manage stress through relaxation or light activity, as chronic stress can slow digestion.

  • Get adequate rest and hydration to allow your body to repair.

  • Discuss diet options such as low-FODMAP or anti-inflammatory eating with your practitioner.

Together, these habits complement the SIBO Protocol and help maintain long-term digestive health.


Why Choose Doctor-Formulated Supplements

Every product in the Priority One SIBO line was created by experienced physicians and manufactured in a CGMP-certified, NSF-audited facility.

  • Dr. Mona Morstein, a naturopathic physician, brings decades of experience in treating gastrointestinal disorders with integrative medicine.

  • Dr. Paul Anderson, a leader in naturopathic and functional medicine research, contributes his expertise in chronic and complex health challenges.

When you choose doctor-formulated supplements, you’re choosing formulas built on science, safety, and clinical insight.


Putting It All Together

The SIBO Protocol is a comprehensive system that supports gut balance step by step:

  1. Eradicate — with Sibotic

  2. Support Motility — with SIBO-MMC

  3. Protect and Rebuild — with SIBO Rebuild

  4. Enhance Digestion — with SIBOZyme or SIBOZyme Chewable

  5. Target Biofilms — with Biofilm Phase 2 Advanced

Each phase builds on the last, working together to help you feel better and maintain a healthier gut environment for the long term.

Shop the complete SIBO Protocol at Priority One Vitamins to start your journey toward lasting gut health and digestive comfort.

The Path to a Healthier Gut

With the Priority One SIBO Protocol, you’re not just taking supplements — you’re following a comprehensive, clinically designed plan for restoring gut balance and long-term digestive health.

Experience the difference of doctor-formulated support and take the next step in your recovery journey today.

FDA Disclaimer:

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FAQs

1. What is the SIBO Protocol?

The SIBO Protocol is a structured, doctor-formulated program that supports gut healing through four key phases — eradication, motility, rebuilding, and digestion.

2. Who created the Priority One SIBO Protocol?

The protocol was developed by Dr. Mona Morstein, a recognized expert in gastrointestinal health, with additional contributions from Dr. Paul Anderson for the biofilm support phase.

3. Can I use all four products together?

The protocol is designed as a system where each phase builds on the previous one. Many people use products from multiple phases as part of a continuous gut support routine.

4. Can I continue taking the products for maintenance?

Many individuals choose to continue enzyme or motility support formulas even after completing the full protocol to maintain digestive wellness.

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