Chronic Histamine Response & How to Support Your Body

Chronic Histamine Response & How to Support Your Body


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Do you often experience allergies, brain fog, headaches, or digestive issues? These could be signs of a chronic histamine response. But what exactly is histamine, and why does it affect your body so strongly? In this post, we’ll explore what histamine is, how it impacts your health, and how you can naturally support your body.


Understanding Histamine

Histamine is a biochemical produced naturally by your immune system. It plays a key role in immune response, digestion, and even acts as a neurotransmitter. While histamine is essential for bodily functions, problems arise when there’s an excess, and your body can’t break it down properly.

The body primarily relies on two enzymes to break down histamine:

  • Diamine Oxidase (DAO) - Found in the gut, it breaks down histamine from food.

  • Histamine N-Methyltransferase (HNMT) - Found in tissues and the liver, it processes histamine in the body.

When these enzymes aren’t functioning well, histamine can build up, leading to various symptoms.


Causes of Chronic Histamine Response

A chronic histamine response can occur due to several factors:

  • Leaky Gut: A compromised gut barrier allows histamine to enter the bloodstream, increasing symptoms.

  • Hormonal Imbalances: High estrogen levels can reduce DAO activity, contributing to histamine intolerance.

  • Liver Dysfunction: The liver is responsible for breaking down histamine. Poor liver function means excess histamine remains in the body.

  • DAO Deficiency: Genetic factors or nutrient deficiencies can lead to low DAO levels, making it harder to break down histamine.


Symptoms of Histamine Intolerance

If histamine builds up, you might experience:

  • Headaches or migraines

  • Skin issues like hives or rashes

  • Digestive problems such as bloating or diarrhea

  • Allergies or sinus congestion

  • Anxiety or mood swings


Supporting Your Body Naturally

The good news is that you can support your body’s ability to manage histamine with the right nutrients and lifestyle changes. Let’s dive into some effective solutions.

1. Vitamin B6 - B Complex

Vitamin B6 is essential for the production of DAO. By ensuring your body has enough B6, you can enhance your ability to break down histamine naturally.

We recommend our B Complex supplement, which provides a comprehensive blend of B vitamins to support enzyme production and overall health.

2. Total Gland Plus

Supporting liver function is key to managing histamine levels. Our Total Gland Plus contains nutrient-dense, grass-fed beef organs like liver, thymus, and kidney, providing the nutrients your body needs to clear excess histamine.


Additional Tips for Histamine Relief

In addition to supplements, consider these tips:

  • Avoid High-Histamine Foods: Fermented foods, aged cheeses, alcohol, and cured meats can worsen symptoms.

  • Support Your Gut: Prioritize a nutrient-dense, anti-inflammatory diet to maintain a healthy gut barrier.

  • Manage Stress: High cortisol levels can trigger histamine release, so practice relaxation techniques.

  • Check for Environmental Triggers: Mold, pollution, and secondhand smoke can contribute to histamine issues.


Chronic histamine intolerance can be challenging, but with the right support, you can reduce symptoms and restore balance. Incorporating supplements like B Complex and Total Gland Plus, combined with a gut-friendly diet and stress management, can make a world of difference.

Ready to take control of your health? 

Visit Priority One Vitamins to learn more and find the best supplements for your needs.

Here’s to a healthier, happier you!


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