5 MTHF (120 Capsules) - the most bio-available and active form of folic acid.*


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5-MTHF is the most bioavailable and active form of folic acid.* It is an essential nutrient that may provide the following benefits:

  • An essential B vitamin that supports methylation.* 
  • 5-MTHF supplement benefits the cysteine cycle.*
  • Used in the regulation of homocysteine.*
  • Stimulation of red blood cell production.*
  • Aids those whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.*
  • Some women may reduce their risk of a neural tube defect pregnancy by consuming folate before and during pregnancy.*

An excellent source of folate for pregnant women. Some women may reduce their risk of a neural tube defect pregnancy by maintaining intakes of folate during their childbearing years.* 

Identify risk factors for neural tube defects:

“Populations at risk. Prevalence rates for neural tube defects have been reported to vary with a wide range of factors including genetics, geography, socioeconomic status, maternal birth cohort, the month of conception, race, nutrition, and maternal health, including maternal age and reproductive history. Women with a close relative (i.e., sibling, niece, nephew) with a neural tube defect, those with insulin-dependent diabetes mellitus, and women with seizure disorders who are being treated with valproic acid or carbamazepine are at significantly increased risk compared with women without these characteristics. Rates for neural tube defects vary within the United States, with lower rates observed on the west coast than on the east coast.”¹

Healthful diets with adequate folate may reduce a woman's risk of having a child with a brain or spinal cord birth defect.* Sources of folate include fruits, vegetables, whole grain products, fortified cereals, and dietary supplements.*

1. Electronic Code of Federal Regulations, https://www.ecfr.gov/




Folate (as (6S)-5-methyltetrahydrofolic acid)(equivalent to 1,852mcg of (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)



WARNING: If you are pregnant or breast feeding, consult your physician before using this product.



Customer Reviews

Based on 4 reviews

Love this product

E. Turner
Great Product

I take this daily and can tell the difference it makes in me.

Debbie Jackson
Great Vitamin

Recommended by my Dr. Works great!

Marcus Inouye
Found supplements

Good what I needed