Folate Methylation | Active B Vitamins, Optifolin+®, Methylcobalamin, TMG & Phosphatidylserine | 60 Vegetarian Capsules

Folate Methylation — Complete Active B Vitamin & Methylation Support with Optifolin+®, Methylcobalamin & TMG

Methylation is one of the most fundamental biochemical processes in the human body — occurring billions of times per second in every cell, and involved in DNA synthesis and repair, neurotransmitter production, homocysteine metabolism, gene expression, detoxification, and immune regulation. When methylation is impaired — through nutritional deficiency, genetic variation (particularly MTHFR), or metabolic insufficiency — the downstream consequences affect virtually every system in the body.*

Folate Methylation is a precision formula built around the specific nutrients that drive and support normal methylation: active forms of all key B vitamins, two patented branded ingredients for maximum bioavailability, trimethylglycine (TMG) as an additional methyl donor, and phosphatidylserine for brain membrane support — delivered in a fully vegetarian capsule.*

Serving size is 2 vegetarian capsules, 30 servings per container (60 capsules).

What's inside and why it matters

Thiamine HCl (Vitamin B1, 50mg, 4,167% DV) — At 50mg — 4,167% of the daily value — thiamine is included at a high-potency dose supporting normal nerve function, energy metabolism, and neurotransmitter synthesis. B1 is a critical cofactor for multiple Krebs cycle enzymes and supports the nervous system function that underpins cognitive health.*

Riboflavin 5 Sodium Phosphate (Vitamin B2, 50mg, 3,846% DV) — The active coenzyme form of riboflavin — riboflavin 5-phosphate (R5P) — is directly usable without the conversion step required for standard riboflavin. This is the form that directly participates in cellular energy metabolism as a component of FMN and FAD coenzymes. Critically, riboflavin 5-phosphate is also essential for the activation of MTHFR — the enzyme that converts folate to its active methylated form. Individuals with MTHFR variants have reduced MTHFR activity, and adequate R5P supports what activity the enzyme retains. At 50mg in active form, this is a meaningful and clinically informed inclusion.*

Niacin as Niacinamide (Vitamin B3, 50mg NE, 313% DV) — The non-flushing amide form of niacin, supporting normal NAD+ production, cellular energy metabolism, DNA repair, and sirtuin activity — enzymes involved in cellular health and longevity.*

Vitamin B6 as Pyridoxal 5 Phosphate (30mg, 1,765% DV) — Pyridoxal 5-phosphate (P5P) is the biologically active coenzyme form of Vitamin B6 — directly usable without hepatic conversion. At 30mg of P5P, this is one of the highest-potency active B6 doses available in a supplement. P5P is essential for normal transsulfuration — the methylation pathway that converts homocysteine to cysteine — making it one of the most important cofactors in the methylation cycle.*

Optifolin+® Folate (as (6S)-5-Methyltetrahydrofolate, Choline Salt, 991mcg DFE / 583mcg Folate, 248% DV) — Optifolin+® is a patented, registered trademark form of active folate from Balchem Corporation — the world's largest manufacturer of active folate. It delivers (6S)-5-methyltetrahydrofolate (L-MTHF) as the choline salt — the biologically active form of folate that enters the methylation cycle directly without requiring MTHFR enzyme conversion.*

Standard supplements use folic acid, which must be converted by MTHFR to L-MTHF before it can be used. Up to 40% of people have MTHFR polymorphisms (C677T and A1298C variants) that significantly impair this conversion — meaning folic acid supplementation may be largely ineffective for this population. Optifolin+® bypasses MTHFR entirely, delivering the end-product form of folate that is immediately available for the methylation cycle regardless of genetic profile. At 991mcg DFE — 248% of the daily value — this is a meaningful, high-potency dose of the most bioavailable folate form available.*

Vitamin B12 as Methylcobalamin (1,000mcg, 41,667% DV) — Methylcobalamin is the neurologically active form of B12 — the form directly involved in the methylation cycle as a cofactor for methionine synthase, the enzyme that converts homocysteine to methionine. At 1,000mcg — 41,667% of the daily value — this provides robust, high-potency B12 support for the methylation cycle, neurological health, and normal homocysteine metabolism.*

Biotin USP (1,000mcg, 3,333% DV) — USP-grade biotin at a high 1,000mcg dose. Biotin is a cofactor for carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid metabolism. At this dose, biotin provides comprehensive coenzyme support for the metabolic pathways that intersect with the methylation cycle.*

Pantothenic Acid as d-Calcium Pantothenate (Vitamin B5, 55mg, 1,100% DV) — At 1,100% of the daily value, pantothenic acid supports normal CoA synthesis — required for energy metabolism, fatty acid synthesis, and adrenal hormone production — all of which are connected to the metabolic demands of normal methylation.*

Choline from Phosphatidylcholine (50mg phosphatidylcholine, providing 3mg choline) — Phosphatidylcholine is the primary phospholipid of cell membranes, included here for its role in supporting normal neuronal membrane integrity and choline availability for acetylcholine synthesis and methyl group donation.*

Zinc as Zinc Bisglycinate Chelate, ALBION® (2mg, 18% DV) — ALBION® is a registered trademark of Albion Labs Inc. — the world leader in mineral amino acid chelation. Zinc bisglycinate chelate is one of the most bioavailable forms of zinc, providing superior absorption over oxide or sulfate forms. Zinc is an essential cofactor for MTHFR and numerous other enzymes in the methylation pathway.*

Trimethylglycine (TMG) / Betaine Anhydrous (500mg) — TMG is a direct methyl donor — it donates one of its three methyl groups to homocysteine in the BHMT pathway (betaine-homocysteine methyltransferase), converting homocysteine to methionine independently of the folate-B12 methylation cycle. This provides a parallel and complementary route for normal homocysteine metabolism that is particularly important when the folate-B12 pathway is under stress or insufficient. At 500mg, this is a meaningful dose of one of the most important direct methyl donors.*

Phosphatidylserine from Sunflower (Helianthus annuus, 100mg, 20% extract) — Phosphatidylserine (PS) is a phospholipid concentrated in brain cell membranes, where it plays a critical role in supporting normal neuronal function, cell signalling, and membrane fluidity. PS is the most extensively researched phospholipid for cognitive support, with clinical research examining its role in supporting normal memory, attention, and cognitive function. Using sunflower-derived PS (rather than soy-derived) makes this formula suitable for those avoiding soy.*

Why active forms are essential in a methylation formula

The methylation cycle is only as effective as the nutrients feeding it — and in each case, the active form of the nutrient is the one that participates directly in the cycle. Folic acid must be converted to L-MTHF; cyanocobalamin must be converted to methylcobalamin; standard riboflavin must be converted to R5P before it can support MTHFR. Folate Methylation uses Optifolin+® (active folate), methylcobalamin (active B12), riboflavin 5-phosphate (active B2), and pyridoxal 5-phosphate (active B6) — ensuring that every cofactor in this formula is in the form that participates directly in normal methylation, without conversion steps that can be impaired by genetic variants or metabolic insufficiency.*

At a glance — what this formula supports

• Normal methylation cycle function via active folate, B12, B6 & B2 cofactors*
• Healthy homocysteine metabolism via folate, methylcobalamin, P5P & TMG*
• Normal gene expression, DNA synthesis & cellular repair via methylation support*
• Cognitive function and brain membrane integrity via phosphatidylserine & choline*
• Normal neurotransmitter synthesis via high-potency active B vitamin cofactors*
• Comprehensive support for MTHFR variant individuals via Optifolin+® & active B vitamins*

Quality you can verify

Every batch of Folate Methylation is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Features Optifolin+® (Balchem Corporation) and ALBION® zinc bisglycinate chelate (Albion Labs Inc.) — two registered, patented branded ingredients.

60 vegetarian capsules per bottle (30 servings).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warnings

WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. If you are taking medications including methotrexate or other folate antagonists, consult your healthcare provider before use. Those with bipolar disorder should consult their healthcare provider before taking high-dose methyl donors.