Mega Stress™ Capsules | Quatrefolic®, High-Potency B Complex, Adrenal Glandular & Licorice 10:1 for Stress & Adrenal Support | 150 Capsules

Mega Stress™ Capsules — High-Potency Active B Complex, Adrenal Glandular & Adaptogenic Support for Comprehensive Stress Resilience

Mega Stress™ Capsules is the vegetarian capsule version of Priority One's flagship adrenal and stress support formula — combining a high-potency, active-form B vitamin complex featuring Quatrefolic® active folate and methylcobalamin B12 with Adrenal glandular concentrate, a high-concentration Licorice root 10:1 extract, adaptogenic Panax ginseng, and key nutritional cofactors for comprehensive adrenal and nervous system support.*

Please note: While the capsule shell is vegetarian (hypromellose), this formula contains Adrenal glandular concentrate — not suitable for those who require an entirely animal-free supplement.

Serving size is 5 vegetarian capsules, 30 servings per container (150 capsules).

What's inside and why it matters

Vitamin C as Ascorbic Acid (500mg, 556% DV) — At 500mg, Vitamin C is a foundational adrenal support nutrient. The adrenal glands have among the highest concentrations of Vitamin C of any tissue in the body, required for normal synthesis of cortisol and other adrenal steroid hormones. During stress, Vitamin C is rapidly depleted from the adrenal cortex.*

Thiamine HCl (Vitamin B1, 99mg, 8,250% DV) — A critical energy metabolism cofactor essential for normal cellular energy production via pyruvate dehydrogenase and the Krebs cycle — foundational for the high-demand adrenal and nervous system during stress.*

Riboflavin (Vitamin B2, 100mg, 7,692% DV) — A critical FAD and FMN coenzyme cofactor for cellular energy metabolism and MTHFR enzyme activity.*

Niacin as Niacinamide (100mg NE, 625% DV) — The non-flushing niacinamide form supporting normal NAD+ production — essential for energy metabolism and adrenal steroid hormone synthesis.*

Vitamin B6 as Pyridoxine HCl (100mg, 5,882% DV) — Supporting normal amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and adrenal cortex function.*

Folate as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt (689mcg DFE, 172% DV) — Quatrefolic® is a patented, registered trademark active folate from Gnosis S.p.A. (US Patent 7,947,662), delivering L-methylfolate directly without requiring MTHFR enzyme conversion — supporting normal methylation and healthy homocysteine metabolism.*

Vitamin B12 as Methylcobalamin (500mcg, 20,833% DV) — The active, neurologically ready form of B12 at a very high dose, supporting normal methylation, neurological function, and neurotransmitter activity.*

Biotin (200mcg, 667% DV) — Supporting normal fatty acid synthesis, carboxylase enzyme function, and adrenal energy metabolism.*

Pantothenic Acid as d-Calcium Pantothenate (500mg, 10,000% DV) — At 10,000% of the daily value, pantothenic acid (Vitamin B5) is the primary standout in this formula. As the precursor to Coenzyme A (CoA) — essential for adrenal steroid hormone synthesis including cortisol, DHEA, and aldosterone — pantothenic acid is traditionally called the "anti-stress vitamin" for its direct role in supporting the adrenal cortex.*

Choline as Choline Bitartrate (45mg, 8% DV) — Supporting normal acetylcholine synthesis and healthy nervous system neurotransmitter function.*

Zinc as Zinc Picolinate (16mg, 145% DV) — One of the most bioavailable zinc forms at 145% DV, supporting normal adrenal enzyme function and cortisol regulation.*

Chromium as Chromium Picolinate (200mcg, 571% DV) — Supporting normal glucose metabolism and healthy insulin sensitivity — both relevant to the adrenal stress response since cortisol dysregulation affects blood sugar balance.*

PABA (Para-Aminobenzoic Acid, 50mg) — Supporting normal folate utilisation and healthy B vitamin metabolism.*

Inositol 97% (100mg) — At 97% purity, supporting normal cellular insulin signalling, healthy serotonin receptor sensitivity, and normal lipid metabolism.*

Bioflavonoids Extract 25% from Bitter Orange fruit (250mg) — A citrus bioflavonoid complex supporting Vitamin C activity, healthy adrenal tissue antioxidant protection, and normal capillary integrity.*

Licorice Root Extract 10:1 (Glycyrrhiza spp., 500mg) — A 10:1 concentrated extract equivalent to 5,000mg of raw licorice root per serving. Licorice root supports normal cortisol availability through inhibition of 11-beta-HSD2 — the enzyme that converts cortisol to inactive cortisone. The 10:1 extraction ratio provides a significantly more concentrated form of this adrenal botanical.*

Please note: This is standard licorice root (not DGL), retaining its glycyrrhizin content. Regular use of high-dose licorice root may affect blood pressure — consult a healthcare provider if relevant.

Asian Ginseng Root Extract 5% Ginsenosides (Panax ginseng, 250mg) — Standardised to 5% ginsenosides, providing 12.5mg of active ginsenosides per serving. Panax ginseng is one of the most extensively researched adaptogens for HPA axis modulation, normal adrenal function, and healthy energy and cognitive performance under stress.*

Adrenal Glandular Concentrate (290mg) — Adrenal cortex tissue concentrate providing tissue-specific factors — adrenal peptides, enzymes, and regulatory proteins — from the site of cortisol, DHEA, and aldosterone synthesis. At 290mg, this is a meaningful glandular dose complementing the formula's extensive nutritional and botanical adrenal support.*

At a glance — what this formula supports

• Normal adrenal steroid hormone synthesis via Pantothenic Acid 500mg & Vitamin C 500mg*
• HPA axis and cortisol support via Adrenal glandular 290mg & Licorice 10:1 500mg*
• Adaptogenic stress resilience via Panax Ginseng 5% ginsenosides*
• Normal nervous system neurotransmitter support via active B complex & Choline*
• Normal methylation via Quatrefolic® active folate & Methylcobalamin B12*
• Normal glucose metabolism relevant to stress response via Chromium Picolinate*

Quality you can verify

Every batch of Mega Stress™ Capsules is manufactured in a GMP-certified facility and third-party tested for purity and potency. Features Quatrefolic® (Gnosis S.p.A., US Patent 7,947,662). Vegetarian capsule shell (hypromellose).

150 capsules per bottle (30 servings).

Please note: Contains Adrenal glandular concentrate.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warnings

WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. Contains standard licorice root (glycyrrhizin-containing) at high concentration — consult your healthcare provider before use if you have hypertension, a cardiovascular condition, oedema, or are taking medications. Contains Adrenal glandular concentrate.