Milk Thistle 500mg — 80% Silymarin Seed Extract for Maximum-Potency Hepatoprotective & Liver Support
Priority One's Milk Thistle 500mg delivers 500mg of Milk Thistle seed extract standardised to 80% silymarin per capsule — providing 400mg of active silymarin per serving. This is among the highest commercially available silymarin doses in a single vegetarian capsule, reflecting a commitment to meaningful, therapeutic-level botanical potency rather than nominal inclusion.*
Serving size is 1 vegetarian capsule, 120 servings per container.
What's inside and why it matters
Milk Thistle Seed Extract 80% Silymarin (Silybum marianum, 500mg per capsule)
Milk thistle (Silybum marianum) is the most extensively researched hepatoprotective botanical in the world, with a clinical research history spanning more than five decades. Its seeds contain the primary active compound complex — silymarin — a mixture of flavonolignans including silybin (the most bioactive component), silychristin, silydianin, and isosilybin.*
Why standardisation to 80% silymarin matters — A standardisation of 80% at 500mg extract weight means each capsule delivers 400mg of active silymarin per serving. At 120 capsules per bottle, this delivers 48,000mg (48 grams) of total silymarin — making this one of the most cost-effective ways to deliver meaningful daily silymarin support.*
Normal liver cell membrane integrity — Silymarin's flavonolignan structure allows it to bind to the outer membrane of hepatocytes, competitively inhibiting the entry of toxins by occupying the same binding sites used by hepatotoxic compounds. This direct membrane protection is the most established and distinctive property of silymarin.*
Normal antioxidant defence in hepatic tissue — Silymarin supports normal glutathione levels in the liver. Glutathione is the liver's master antioxidant and primary Phase II detoxification cofactor. Silymarin both inhibits the depletion of hepatic glutathione and supports its regeneration — a dual mechanism that meaningfully supports the liver's own antioxidant defences.*
Normal liver cell regeneration — Silymarin stimulates ribosomal RNA synthesis in hepatocytes via RNA polymerase I activation — supporting normal protein synthesis and normal liver cell renewal. Silymarin actively supports the regenerative capacity of the liver, not merely protecting existing liver cells.*
Normal inflammatory balance in hepatic tissue — Silymarin inhibits leukotriene synthesis via 5-lipoxygenase inhibition and modulates normal NF-κB pathway activity in hepatic tissue — supporting normal inflammatory balance within the liver.*
Normal bile secretion and hepatic flow — Supporting normal bile production and healthy bile flow from the liver, relevant to fat digestion, cholesterol metabolism, and the normal elimination of metabolic waste via bile.*
400mg active silymarin per capsule — Most clinical research on silymarin uses doses in the range of 200–420mg of active silymarin per day. At 400mg in a single capsule, Milk Thistle 500mg delivers the full clinically researched range in one capsule, making dose management simple and flexible.*
At a glance — what this formula supports
- Normal liver cell membrane integrity and hepatocyte protection via silymarin*
- Normal hepatic glutathione levels and antioxidant defence*
- Normal liver cell regeneration and protein synthesis*
- Normal inflammatory balance in hepatic tissue*
- Normal bile production and healthy hepatic flow*
- Comprehensive liver wellness as part of a healthy lifestyle*
Quality you can verify
Every batch of Milk Thistle 500mg is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Standardised to 80% silymarin — 400mg active silymarin per capsule — verified by HPLC analysis.
120 vegetarian capsules per bottle.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. If you have a liver condition, bile duct obstruction, or are taking medications, consult your healthcare provider before use.
