Urinary Tranquility™ | Curcumin C3 Reduct®, Quercetin 95%, Exocyan Cran™, Arginine, Glucosamine & Multi-Botanical Urinary Comfort | 90 Vegetarian Capsules

Urinary Tranquility™ — Curcumin C3 Reduct® ODN 95%, Quercetin 95%, Exocyan Cran™, Arginine, Bioflavonoids & Multi-Botanical Urinary Comfort & Tract Health Formula

Urinary Tranquility™ is Priority One's comprehensive urinary comfort and tract health formula — a more expansive urinary support formula than Urinary Defense™, adding targeted antioxidant and anti-inflammatory support (Curcumin C3 Reduct® ODN, Quercetin 95%, Bioflavonoids), L-Arginine for normal nitric oxide and urinary tract smooth muscle support, Glucosamine HCl for normal glycosaminoglycan (GAG) layer support, and Oregon Grape root berberine — alongside the established Urinary Defense™ core of Exocyan Cran™ cranberry, Juniper berry, Parsley, Uva Ursi, Marshmallow root, Ginger, and Olive Leaf.*

Serving size is 3 vegetarian capsules, 30 servings per container (90 capsules).

What's inside and why it matters

Vitamin A as Beta-Carotene (600mcg RAE, 67% DV) — Beta-carotene converted to Vitamin A on demand, supporting normal urinary tract epithelial cell integrity and healthy mucosal barrier maintenance — Vitamin A is one of the most critical nutrients for normal epithelial differentiation throughout the urogenital tract.*

Arginine Monohydrochloride (500mg per serving) — L-Arginine is the sole precursor for endogenous nitric oxide (NO) synthesis via nitric oxide synthase (NOS). In the urinary tract, NO is produced by the urothelium (bladder epithelium) and supports normal urinary tract smooth muscle relaxation, healthy bladder capacity, and normal urinary epithelial defence against bacterial adhesion. NO also has direct antimicrobial activity against uropathogenic bacteria by forming reactive nitrogen species that damage bacterial DNA and membranes. At 500mg — the highest-dosed active ingredient in this formula — L-Arginine supports the nitric oxide-dependent dimension of urinary tract mucosal defence.*

Bioflavonoids Extract 25% from Bitter Orange fruit (500mg per serving) — A 25% standardised bioflavonoid complex providing 125mg of active bioflavonoids per serving. Citrus bioflavonoids support normal capillary integrity and vascular permeability in the urinary tract mucosa, normal mast cell stability, and healthy urinary tissue antioxidant protection.*

Quercetin Extract 95% from Japanese Sophora flower bud (400mg per serving) — At 95% purity and 400mg — providing 380mg of pure quercetin per serving. Quercetin is the most extensively studied flavonoid for interstitial cystitis (IC) and urinary tract inflammatory balance. Its primary mechanisms include normal NF-κB pathway regulation, normal mast cell stabilisation (mast cell activation plays a central role in bladder discomfort), and normal NLRP3 inflammasome activity. At 400mg of 95% quercetin, Urinary Tranquility provides the highest quercetin dose in the Priority One range — reflecting its specific relevance to urinary tract comfort and normal inflammatory balance.*

Juniper Berry (Juniperus communis, 200mg per serving) — Supporting normal kidney function and healthy urinary antiseptic activity via terpinen-4-ol, which is excreted through the kidneys and provides direct urinary tract antimicrobial support.*

Parsley Leaf (Petroselinum crispum, 120mg per serving) — Supporting normal urine output, healthy renal blood flow, and normal urinary tract antioxidant protection via apigenin and luteolin flavonoids.*

Curcumin C3 Reduct® ODN Extract 95% (Turmeric rhizome, 100mg per serving) — Curcumin C3 Reduct® is a registered trademark of Sabinsa Corporation — one of the world's leading botanical ingredient companies. C3 Reduct® is the tetrahydrocurcumin (THC) form of curcumin — the fully reduced (hydrogenated) curcuminoid that is colourless and significantly more water-soluble and bioavailable than standard curcumin.*

Tetrahydrocurcumin is the primary metabolite to which curcumin is converted in vivo, and it has superior antioxidant activity compared to curcumin itself — particularly as a free radical scavenger (the ODN designation stands for Oxidative Damage Neutraliser). In the urinary tract context, C3 Reduct® provides targeted antioxidant and normal inflammatory balance support in urinary tract tissues with better bioavailability than conventional curcumin extracts.*

Glucosamine HCl (100mg per serving) — Glucosamine is the primary substrate for the synthesis of glycosaminoglycans (GAGs) — the negatively charged polysaccharide chains that form the protective mucus layer lining the inner surface of the bladder. This GAG layer is the bladder's primary defence against urinary irritants and bacterial adhesion. Glucosamine HCl supplementation supports the normal replenishment of this GAG layer — a clinically targeted approach for normal bladder mucosal barrier integrity.*

Exocyan Cran™ Cranberry Fruit Extract 1.5% Proanthocyanidins (Vaccinium macrocarpon, 100mg per serving) — Exocyan Cran™ is a registered trademark of Nexira, providing standardised cranberry extract at 1.5% proanthocyanidins. Cranberry PAC-A inhibits P-fimbriae adhesion of uropathogenic E. coli to uroepithelial cells — the primary mechanism by which cranberry supports normal urinary tract microbial balance.*

Uva Ursi Leaf (Arctostaphylos uva ursi, 50mg per serving) — Providing arbutin → hydroquinone in alkaline urine for direct urinary antimicrobial support in the renal tubule and bladder.*

Marshmallow Root Extract 4:1 (Althaea officinalis, 45mg per serving) — A 4:1 concentrated extract providing mucilaginous polysaccharides for normal urinary mucosal demulcent, soothing, and epithelial hydration support.*

Oregon Grape Root (Mahonia aquifolium, 40mg per serving) — Oregon Grape root is one of the primary natural berberine sources, with berberine providing DNA intercalation-based antimicrobial activity against gram-positive and gram-negative bacteria including uropathogens. Oregon Grape's berberine content complements the other urinary antimicrobial botanicals in this formula through a distinct mechanism.*

Ginger Root (Zingiber officinale, 40mg per serving) — Supporting normal renal blood flow, healthy kidney function, and normal urinary smooth muscle function via gingerols and shogaols.*

Olive Leaf Extract 20% Oleuropein (Olea europaea, 20mg per serving) — Standardised to 20% oleuropein providing 4mg of active oleuropein per serving for broad-spectrum antimicrobial membrane disruption activity and normal mucosal immune support.*

Urinary Tranquility™ vs Urinary Defense™

Urinary Defense™ provides the seven-botanical urinary antimicrobial and mucosal core. Urinary Tranquility™ extends this with four additional dimensions of urinary tract support: (1) L-Arginine for normal urinary NO synthesis and smooth muscle relaxation; (2) Quercetin 95% 400mg and C3 Reduct® ODN curcumin for normal urinary tract inflammatory balance and mast cell support; (3) Glucosamine HCl for normal bladder GAG layer replenishment; and (4) Oregon Grape root berberine for additional antimicrobial depth. Urinary Tranquility™ is appropriate for individuals seeking broader, more comprehensive urinary comfort and tract support.*

At a glance — what this formula supports

• Normal urinary tract mucosal defence via Exocyan Cran™ PAC-A anti-adhesion, Uva Ursi & Oregon Grape berberine*
• Normal bladder GAG layer replenishment via Glucosamine HCl*
• Normal urinary smooth muscle function and NO synthesis via L-Arginine 500mg*
• Normal urinary tract inflammatory balance via Quercetin 95% 400mg & Curcumin C3 Reduct® ODN*
• Normal mast cell stability and urinary comfort via Quercetin & Bioflavonoids*
• Normal urinary tract epithelial integrity via Vitamin A beta-carotene & Marshmallow root 4:1*

Quality you can verify

Every batch of Urinary Tranquility™ is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Features Curcumin C3 Reduct® (Sabinsa Corporation) and Exocyan Cran™ (Nexira) — two registered trademark branded ingredients.

90 vegetarian capsules per bottle (30 servings).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warnings

WARNING: If you are pregnant or breastfeeding, consult your physician before using this product — contains Uva Ursi and Juniper berry (traditionally avoided in pregnancy). If you have kidney disease, a diagnosed bladder condition, or are taking any medications, consult your healthcare provider before use. Not intended to replace medical treatment for urinary tract infections or interstitial cystitis.