Zinc Orotate — High-Potency Zinc 51mg from Zinc Orotate Oxide for Immune Function, Hormone Health & Comprehensive Zinc Nutrition
Priority One's Zinc Orotate provides 51mg of elemental zinc per capsule — 340% of the daily value — in the enhanced cellular delivery orotate form. A high-potency, single-ingredient zinc supplement providing meaningful zinc nutrition in a clean, fully vegetarian formula.*
Serving size is 1 vegetarian capsule, 100 servings per container.
What's inside and why it matters
Zinc as Zinc Orotate Oxide (51mg elemental Zinc per capsule, 340% DV)
Zinc is an essential trace mineral required as a catalytic cofactor for over 300 enzymatic reactions in the human body — more than any other trace mineral. It plays roles in virtually every physiological system.*
Zinc Orotate — enhanced cellular delivery — Zinc Orotate is zinc chelated with orotic acid (Vitamin B13) — the same orotic acid transport mechanism used in Priority One's Magnesium Orotate, Calcium Orotate, and Potassium Orotate products. Orotic acid is a naturally occurring compound involved in pyrimidine synthesis that serves as a molecular carrier for mineral transport across cell membranes.*
Orotic acid salts are theorised to improve cellular delivery of mineral ions by facilitating transport across the lipid bilayer — potentially providing superior intracellular zinc bioavailability compared to inorganic zinc salts (zinc oxide, zinc sulphate) and comparable or superior bioavailability to standard organic chelates (zinc citrate, zinc gluconate). The addition of zinc oxide in this blended form (zinc orotate oxide) provides additional elemental zinc concentration per capsule.*
Zinc at 340% DV — why a high-potency zinc supplement? — The DV for zinc (11mg for men, 8mg for women) represents the minimum requirement to prevent deficiency, not an optimal therapeutic or supplemental dose. Published research on zinc's clinical applications — including immune function, wound healing, hormone synthesis, and metabolic function — has typically used doses in the 25–50mg elemental zinc range. At 51mg (340% DV), Zinc Orotate provides a high-potency zinc dose appropriate for individuals with documented zinc insufficiency or those whose healthcare provider has recommended higher-dose zinc supplementation.*
Zinc and normal immune function — Zinc is one of the most important nutritional regulators of immune function. It is a required cofactor for the thymulin thymic peptide (which requires zinc for its biological activity), supports normal T-cell development and lymphocyte proliferation, normal natural killer cell activity, normal neutrophil function, and is directly required for over 100 immune-relevant zinc-finger transcription factors. Zinc deficiency — even marginal deficiency — impairs immune function significantly.*
Zinc and normal hormonal function — Zinc is specifically concentrated in the testes and prostate (the highest zinc concentrations in the male body), where it is required for normal testosterone synthesis, normal sperm production, and normal prostate cell metabolism. Zinc is also required for normal insulin synthesis and packaging in pancreatic beta cells (insulin is stored as a zinc-insulin hexamer), and supports normal growth hormone and IGF-1 signalling.*
Zinc and normal antioxidant defence — Zinc is a structural component of Cu/Zn-Superoxide Dismutase (Cu/Zn-SOD) — the primary cytoplasmic antioxidant enzyme that converts superoxide radical to hydrogen peroxide. Normal Cu/Zn-SOD activity depends directly on adequate zinc availability.*
Zinc and normal wound healing and tissue repair — Zinc is required for normal collagen synthesis (via prolyl hydroxylase enzyme activity), normal fibroblast proliferation, normal epithelial cell regeneration, and normal keratinocyte differentiation. It is one of the most important trace minerals for normal skin integrity and wound healing.*
Zinc and normal DNA synthesis and cell division — Zinc finger proteins are the largest family of transcription factors in the human genome — with over 700 zinc finger proteins regulating gene expression in virtually every cell type. Normal DNA polymerase, RNA polymerase, and reverse transcriptase activity all require zinc as a structural and catalytic cofactor.*
Zinc and normal taste and smell — Zinc is specifically required for the function of gustin (carbonic anhydrase VI) — the zinc metalloprotein responsible for normal taste and smell function. Zinc deficiency is the most common nutritional cause of hypogeusia (impaired taste).*
At a glance — what this formula supports
- Normal immune function via zinc-dependent T-cell, NK cell & neutrophil activity*
- Normal antioxidant defence via Cu/Zn-SOD metalloenzyme activity*
- Normal testosterone synthesis and reproductive health in men*
- Normal insulin synthesis and healthy glucose metabolism*
- Normal wound healing, collagen synthesis & tissue repair*
- Normal DNA synthesis and gene expression via zinc-finger transcription factors*
Quality you can verify
Every batch of Zinc Orotate is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Single-ingredient formula — 51mg elemental Zinc from Zinc Orotate Oxide per capsule.
100 vegetarian capsules per bottle.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. Do not exceed recommended doses without healthcare provider guidance — chronic high-dose zinc supplementation (above 40mg/day long-term) can interfere with copper absorption. If taking zinc long-term at high doses, consider periodic copper supplementation under healthcare provider guidance. Keep out of reach of children.
