How to Take the SIBO Protocol: A Step-by-Step Guide to Eradication, Protection, and Gut Healing

How to Take the SIBO Protocol: A Step-by-Step Guide to Eradication, Protection, and Gut Healing


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A Step-by-Step Guide to Eradication, Protection, and Gut Healing

Small Intestinal Bacterial Overgrowth (SIBO) is a condition that affects thousands of people, disrupting digestion and causing persistent bloating, discomfort, and fatigue. At Priority One Vitamins, our SIBO Protocol was developed by leading functional medicine experts to help restore balance to the gut through a structured, multi-phase approach that supports every stage of recovery — from eradication to rebuilding.

Formulated by Dr. Mona Morstein, a pioneer in naturopathic gastrointestinal health, and Dr. Paul Anderson, an authority in integrative medicine, this protocol combines clinical insight with practitioner-grade formulations designed to help you feel your best again.


Understanding SIBO

SIBO occurs when bacteria that normally live in the large intestine migrate into the small intestine. This imbalance can interfere with digestion and absorption, leading to symptoms such as bloating, gas, abdominal pain, food sensitivities, and nutrient deficiencies.

Treating SIBO effectively requires more than simply reducing bacterial overgrowth. A long-term solution involves supporting digestion, motility, and the integrity of the intestinal lining — all of which are covered by the Priority One SIBO Protocol.


The Doctor-Formulated Four-Phase SIBO Protocol

This system was carefully designed by Dr. Mona Morstein to target the root causes of SIBO and to support healing at every stage of the process. Each phase plays a vital role in restoring gut balance and long-term wellness.


Phase 1 – Eradication (Sibotic) 

SIBOtic (180 Vegetarian Capsules) - Step 1: Sibo eradication bacteria-balancing ingredients*

SIBOtic (180 Vegetarian Capsules) - Step 1: Sibo eradication bacteria-balancing ingredients*

$85.00

SIBOtic – Step 1 in the SIBO Support Protocol with Dr. Mona Morstein* Developed in collaboration with Dr. Mona Morstein, a recognized expert in gastrointestinal health, SIBOtic is a botanically-based, high-potency formula designed to address the first phase of gut… read more

The first step focuses on rebalancing the microbiome and reducing the bacterial overgrowth that contributes to SIBO.

Sibotic, formulated by Dr. Mona Morstein, combines targeted botanical ingredients and nutrients that support the body’s natural cleansing processes and microbial balance.

This phase helps clear the way for better digestion and prepares the gut for repair and recovery.

Shop Sibotic now to begin your eradication phase.


Phase 2 – Motility Support (SIBO-MMC) 

SIBO-MMC (180 Vegetarian Capsules) - Step 2: Support Digestive Motility and Prevent Recurrence*

SIBO-MMC (180 Vegetarian Capsules) - Step 2: Support Digestive Motility and Prevent Recurrence*

$60.00

SIBO-MMC™ – Step 2: Support Digestive Motility and Prevent Recurrence* Developed in collaboration with Dr. Mona Morstein, a leading expert in gastrointestinal health, SIBO-MMC™ is the second step in the Priority One SIBO Support Protocol, designed to help maintain small… read more

Once the overgrowth is under control, it’s essential to help the digestive system maintain normal movement through the Migrating Motor Complex (MMC). When the MMC functions properly, food and bacteria are moved efficiently through the small intestine, helping prevent relapse.

SIBO-MMC, created by Dr. Mona Morstein, is designed to encourage healthy motility and support long-term digestive comfort.

This phase helps ensure that bacteria do not build up again after treatment.

Shop SIBO-MMC today to support healthy gut movement and maintain progress.


Phase 3 – Protection and Rebuilding (SIBO Rebuild)

SIBO-Rebuild (180 Vegetarian Capsules) - Step 3: Gut Lining and Nerve Regeneration Support*

SIBO-Rebuild (180 Vegetarian Capsules) - Step 3: Gut Lining and Nerve Regeneration Support*

$65.00

SIBO-Rebuild™ – Step 3: Gut Lining and Nerve Regeneration Support* Formulated in collaboration with Dr. Mona Morstein, a leading authority in gastrointestinal health, SIBO-Rebuild™ is the third step in the Priority One SIBO Support Protocol, focused on restoring gut integrity… read more

After addressing the overgrowth and restoring motility, it’s time to strengthen and nourish the intestinal lining.

SIBO Rebuild, also formulated by Dr. Mona Morstein, provides nutrients and botanicals that support the gut barrier and promote repair. It’s a crucial step for nutrient absorption, immune balance, and ongoing digestive wellness.

This phase helps fortify the digestive system and maintain long-term results.

Shop SIBO Rebuild now to promote gut repair and lasting resilience.


Phase 4 – Digestive Support (SIBOZyme and SIBOZyme no HCL)

SIBOZyme No HCL (180 Vegetarian Capsules) Support for healthy digestion in patients seeking small intestinal bacterial balance.*

SIBOZyme No HCL (180 Vegetarian Capsules) Support for healthy digestion in patients seeking small intestinal bacterial balance.*

$100.00

SIBOZyme™ (No HCL) – Targeted Digestive Enzyme Support for Gut Balance* By popular request, SIBOZyme™ (No HCL) expands our exclusive line of digestive health formulas developed in collaboration with Dr. Mona Morstein, a recognized expert in small intestinal and gastrointestinal… read more

SIBOZyme (180 Capsules) - Support healthy digestion in patients seeking small intestinal bacterial balance.*

SIBOZyme (180 Capsules) - Support healthy digestion in patients seeking small intestinal bacterial balance.*

$100.00

SIBOZyme™ – Comprehensive Digestive Enzyme Support with HCL* Formulated in collaboration with Dr. Mona Morstein, a leading authority in gastrointestinal health, SIBOZyme™ is designed to support optimal digestion and promote a healthy intestinal environment for those seeking microbial balance and… read more

Digestive enzyme activity can be impaired during and after SIBO recovery, leading to lingering discomfort or bloating after meals.

SIBOZyme and SIBOZyme no HCL, both created by Dr. Mona Morstein, provide comprehensive enzyme support to help the body break down food efficiently and absorb nutrients.

These formulas can be used throughout all stages of the protocol to promote smooth digestion and comfort after eating. Some individuals with Sibo react better to the formula without HCL. 

Shop SIBOZyme or SIBOZyme no HCL to enhance digestive performance and daily comfort.


For Stubborn or Recurrent Cases (Biofilm Phase 2 Advanced)

Biofilm Phase-2 Advanced™ (60 Capsules) - Clinical-Strength Biofilm Disruptor for Advanced Microbial Support*

Biofilm Phase-2 Advanced™ (60 Capsules) - Clinical-Strength Biofilm Disruptor for Advanced Microbial Support*

$45.00

Biofilm Phase-2 Advanced – Clinical-Strength Biofilm Disruptor for Advanced Microbial Support* Formulated by Dr. Paul S. Anderson, N.D. Biofilm Phase-2 Advanced is a physician-formulated supplement designed to support the body’s natural ability to break down and disrupt advanced biofilm formations—the… read more

Some individuals experience persistent SIBO because bacteria form protective layers called biofilms. These biofilms can make it harder to reach and address the imbalance effectively.

Biofilm Phase 2 Advanced, developed by Dr. Paul Anderson, contains specialized enzymes and compounds designed to help disrupt these biofilms, allowing other supplements in the protocol to work more efficiently.

For difficult or recurring cases, this formula can be used alongside the eradication phase under practitioner guidance.

Shop Biofilm Phase 2 Advanced to strengthen your SIBO support plan.


Supporting Gut Recovery Naturally

In addition to following the SIBO Protocol, lifestyle and dietary habits play a key role in lasting results. Consider these supportive strategies:

  • Eat balanced meals and allow several hours between them to promote gut motility.

  • Manage stress through relaxation or light activity, as chronic stress can slow digestion.

  • Get adequate rest and hydration to allow your body to repair.

  • Discuss diet options such as low-FODMAP or anti-inflammatory eating with your practitioner.

Together, these habits complement the SIBO Protocol and help maintain long-term digestive health.


Why Choose Doctor-Formulated Supplements

Every product in the Priority One SIBO line was created by experienced physicians and manufactured in a CGMP-certified, NSF-audited facility.

  • Dr. Mona Morstein, a naturopathic physician, brings decades of experience in treating gastrointestinal disorders with integrative medicine.

  • Dr. Paul Anderson, a leader in naturopathic and functional medicine research, contributes his expertise in chronic and complex health challenges.

When you choose doctor-formulated supplements, you’re choosing formulas built on science, safety, and clinical insight.


Putting It All Together

The SIBO Protocol is a comprehensive system that supports gut balance step by step:

  1. Eradicate — with Sibotic

  2. Support Motility — with SIBO-MMC

  3. Protect and Rebuild — with SIBO Rebuild

  4. Enhance Digestion — with SIBOZyme or SIBOZyme Chewable

  5. Target Biofilms — with Biofilm Phase 2 Advanced

Each phase builds on the last, working together to help you feel better and maintain a healthier gut environment for the long term.

Shop the complete SIBO Protocol at Priority One Vitamins to start your journey toward lasting gut health and digestive comfort.

The Path to a Healthier Gut

With the Priority One SIBO Protocol, you’re not just taking supplements — you’re following a comprehensive, clinically designed plan for restoring gut balance and long-term digestive health.

Experience the difference of doctor-formulated support and take the next step in your recovery journey today.

FDA Disclaimer:

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FAQs

1. What is the SIBO Protocol?

The SIBO Protocol is a structured, doctor-formulated program that supports gut healing through four key phases — eradication, motility, rebuilding, and digestion.

2. Who created the Priority One SIBO Protocol?

The protocol was developed by Dr. Mona Morstein, a recognized expert in gastrointestinal health, with additional contributions from Dr. Paul Anderson for the biofilm support phase.

3. Can I use all four products together?

The protocol is designed as a system where each phase builds on the previous one. Many people use products from multiple phases as part of a continuous gut support routine.

4. Can I continue taking the products for maintenance?

Many individuals choose to continue enzyme or motility support formulas even after completing the full protocol to maintain digestive wellness.

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