Mega Stress™ — High-Potency Active B Complex, Adrenal Glandular, Adaptogens & Cofactors for Comprehensive Stress Resilience & Adrenal Support
Mega Stress™ (60 Tablets) is a comprehensive adrenal and stress support formula combining a high-potency, active-form B vitamin complex — with Quatrefolic® active folate and methylcobalamin B12 — with Adrenal glandular concentrate, adaptogenic Panax ginseng, licorice root, and supporting nutritional cofactors including ChromeMate® chromium, zinc, and inositol. This is a formula designed to support the nutritional demands of the adrenal axis and nervous system during periods of physiological and psychological stress.*
Please note: Contains Adrenal glandular concentrate — not suitable for vegetarians or vegans. Delivered as a tablet.
Serving size is 2 tablets.
What's inside and why it matters
Vitamin C as Ascorbic Acid (485mg, 539% DV) — At 485mg, Vitamin C is a foundational adrenal support nutrient. The adrenal glands have among the highest concentrations of Vitamin C of any tissue in the body, and Vitamin C is required for the normal synthesis of cortisol and other adrenal steroid hormones. During stress, Vitamin C is rapidly depleted from the adrenal cortex.*
Thiamine HCl (Vitamin B1, 99mg, 8,250% DV) — A critical energy metabolism cofactor essential for pyruvate dehydrogenase and the Krebs cycle enzymes that support normal cellular energy production — foundational for the high-demand adrenal and nervous system during stress.*
Riboflavin (Vitamin B2, 100mg, 7,692% DV) — A critical cofactor for FAD and FMN coenzymes involved in energy metabolism and MTHFR enzyme activity.*
Niacin as Niacinamide (100mg NE, 625% DV) — The non-flushing niacinamide form supporting normal NAD+ production — the cellular coenzyme essential for energy metabolism and adrenal steroid hormone synthesis.*
Vitamin B6 as Pyridoxine HCl (98mg, 5,765% DV) — A high-potency B6 dose supporting normal amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and adrenal cortex function.*
Folate as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt (680mcg DFE, 170% DV) — Quatrefolic® is a patented, registered trademark active folate from Gnosis S.p.A. (US Patent 7,947,662) — the most bioavailable form of L-methylfolate, bypassing the MTHFR enzyme entirely. Supporting normal methylation and homocysteine metabolism.*
Vitamin B12 as Methylcobalamin (500mcg, 20,833% DV) — The active, neurologically ready form of B12 at a very high 500mcg dose, supporting normal methylation, neurological function, and neurotransmitter activity.*
Biotin (200mcg, 667% DV) — Supporting normal fatty acid synthesis, carboxylase enzyme function, and adrenal energy metabolism.*
Pantothenic Acid as d-Calcium Pantothenate (500mg, 10,000% DV) — At 500mg — 10,000% of the daily value — pantothenic acid is the standout nutrient in this formula. Pantothenic acid (Vitamin B5) is the precursor to Coenzyme A (CoA) — essential for the synthesis of adrenal steroid hormones including cortisol, DHEA, and aldosterone. Without adequate pantothenic acid, adrenal steroid synthesis is impaired. Pantothenic acid is traditionally called the "anti-stress vitamin" specifically because of this adrenal cortisol support role.*
Choline from Choline Bitartrate (45mg, 8% DV) — Supporting normal acetylcholine synthesis and healthy nervous system neurotransmitter function.*
Zinc as Zinc Oxide Picolinate (16mg, 145% DV) — Zinc picolinate in a bioavailable form at 145% DV, supporting normal adrenal enzyme function and normal cortisol regulation.*
ChromeMate® Chromium (as chromium chloride hexahydrate polynicotinate, 200mcg, 571% DV) — ChromeMate® is a patented, registered trademark form of chromium from InterHealth Nutraceuticals at 571% DV, supporting normal glucose metabolism and healthy insulin sensitivity — both relevant to the adrenal stress response since cortisol dysregulation affects blood sugar balance.*
PABA (Para-Aminobenzoic Acid, 50mg) — Supporting normal folate utilisation and healthy B vitamin metabolism.*
Inositol (100mg) — Supporting normal cellular signalling, healthy serotonin receptor sensitivity, and normal lipid metabolism.*
Bioflavonoids Extract 25% from Bitter Orange fruit (250mg) — A citrus bioflavonoid complex supporting Vitamin C activity, healthy adrenal tissue antioxidant protection, and normal capillary integrity.*
Licorice Root (Glycyrrhiza glabra, 500mg) — The highest-dosed botanical in this formula. Licorice root is a primary adrenal support botanical whose mechanisms include inhibition of 11-beta-HSD2 — the enzyme that converts cortisol to inactive cortisone — supporting normal cortisol availability at the tissue level. At 500mg, licorice root provides a substantial adrenal-supportive botanical dose.*
Asian Ginseng Root Extract 5% Ginsenosides (Panax ginseng, 250mg) — Standardised to 5% ginsenosides, providing 12.5mg of active ginsenosides per serving. Panax ginseng is one of the most extensively researched adaptogens, supporting the body's normal ability to resist physical and psychological stress via HPA axis modulation, normal adrenal function, and healthy energy and cognitive performance under stress.*
Adrenal Glandular Concentrate (290mg) — The glandular component that distinguishes this formula from a standard high-potency B complex. Adrenal glandular concentrate provides tissue-specific factors from the adrenal cortex — the site of cortisol, DHEA, and aldosterone synthesis — including naturally occurring adrenal peptides, enzymes, and regulatory proteins. At 290mg, this is a meaningful adrenal glandular dose that complements the nutritional and botanical adrenal support throughout the formula.*
At a glance — what this formula supports
- Normal adrenal steroid hormone synthesis via Pantothenic Acid 500mg & Vitamin C 485mg*
- HPA axis and cortisol support via Adrenal glandular 290mg & Licorice root 500mg*
- Adaptogenic stress resilience via Panax Ginseng 5% ginsenosides*
- Normal nervous system neurotransmitter support via active B complex & Choline*
- Normal methylation via Quatrefolic® active folate & Methylcobalamin B12*
- Normal glucose metabolism relevant to stress response via ChromeMate® chromium*
Quality you can verify
Every batch of Mega Stress™ is manufactured in a GMP-certified facility and third-party tested for purity and potency. Features Quatrefolic® (Gnosis S.p.A., US Patent 7,947,662) and ChromeMate® (InterHealth Nutraceuticals).
60 tablets per bottle.
Please note: Contains Adrenal glandular concentrate — not suitable for vegetarians or vegans.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, consult your physician before using this product. This formula contains standard licorice root (glycyrrhizin-containing) at 500mg — with regular use this may affect blood pressure; consult your healthcare provider before use if you have hypertension, a cardiovascular condition, or are taking medications. Not suitable for vegetarians or vegans.
