SIBOtic™ — Four-Compound Botanical Antimicrobial Complex for SIBO Treatment Support by Dr. Morstein
SIBOtic™ is the antimicrobial treatment component of Dr. Mona Morstein ND's SIBO protocol — a high-dose, four-compound botanical antimicrobial formula providing broad-spectrum activity against the bacteria and/or archaea responsible for SIBO. Each of the four active ingredients has documented broad-spectrum antimicrobial activity and a distinct primary mechanism, providing comprehensive coverage across the diverse microbial profiles seen in SIBO.*
Serving size is 6 vegetarian capsules, 30 servings per container (180 capsules).
SIBO — why targeted antimicrobial support matters
Small Intestinal Bacterial Overgrowth (SIBO) is characterised by abnormal colonisation of the small intestine by bacteria (and/or archaea in methane-dominant SIBO). These organisms ferment carbohydrates and proteins in the small intestine, producing hydrogen, methane, and hydrogen sulphide gases that cause bloating, altered bowel habits, and nutrient malabsorption. Effective SIBO treatment requires reducing the bacterial or archaeal load — a task addressable with high-dose botanical antimicrobial protocols.*
What's inside and why it matters
Garlic Bulb Extract 1% Allicin (Allium sativum, 1,500mg per serving) — The highest-dosed ingredient in this formula. 1,500mg of garlic extract standardised to 1% allicin — providing 15mg of active allicin per serving. Allicin is one of the most potent natural antimicrobial compounds known, with broad-spectrum activity against gram-positive and gram-negative bacteria, fungi, and archaea. Allicin penetrates microbial cell membranes and reacts with thiol-containing enzymes via its thiosulfinate group — irreversibly inhibiting essential microbial metabolic enzymes through a mechanism distinct from antibiotics, meaning there is no cross-resistance with pharmaceutical antibiotics. Allicin specifically has documented activity against methane-producing archaea (Methanobrevibacter smithii) — the primary organism responsible for methane-dominant SIBO.*
Berberine HCl 97% from Coptis chinensis root (500mg per serving) — At 500mg of 97% purity — providing 485mg of pure berberine per serving. Berberine is one of the most extensively studied botanical antimicrobial compounds, with published clinical research specifically in SIBO. Berberine intercalates into bacterial DNA, inhibiting DNA replication and RNA transcription; it also inhibits FtsZ — the bacterial cell division protein — preventing bacterial proliferation. A notable clinical trial demonstrated berberine's equivalence to rifaximin in hydrogen-dominant SIBO eradication rates.*
Caprylic Acid from Sodium Hydroxide Caprylate (300mg per serving) — Caprylic acid (C8:0 — octanoic acid) is a medium-chain saturated fatty acid naturally occurring in coconut oil. As a medium-chain fatty acid, caprylic acid inserts into microbial phospholipid bilayers, disrupting membrane integrity, causing membrane depolarisation, and inhibiting fatty acid synthesis. Caprylic acid is particularly valuable in SIBO presentations with a fungal (Candida) co-colonisation component — a common finding in SIBO patients.*
Oregano Leaf Oil (Origanum vulgare spp., 300mg per serving) — Oregano essential oil providing carvacrol (typically 60–80% of oregano oil) and thymol as the primary active compounds. Carvacrol and thymol are phenolic monoterpenoids that penetrate and disrupt microbial cell membranes, disrupting the proton motive force and membrane potential, causing ion leakage and ultimately cell lysis. Oregano oil has documented broad-spectrum activity against gram-positive, gram-negative bacteria, and Candida species, working synergistically with caprylic acid's membrane activity.*
Four mechanisms — comprehensive antimicrobial coverage
SIBOtic™ targets SIBO-associated organisms through four distinct and complementary mechanisms: (1) thiol enzyme alkylation via allicin (Garlic); (2) DNA intercalation and FtsZ inhibition via berberine; (3) membrane phospholipid disruption via caprylic acid; and (4) membrane potential disruption via oregano oil carvacrol and thymol. This four-mechanism approach reduces the likelihood of resistance and provides activity across hydrogen-producing bacteria, methane-producing archaea, and fungal co-colonisers.*
At a glance — what this formula supports
- Broad-spectrum SIBO antimicrobial support via four distinct mechanisms*
- Activity against hydrogen-dominant SIBO bacteria via Berberine HCl 500mg & Garlic allicin*
- Activity against methane-dominant SIBO archaea via Garlic allicin*
- Membrane integrity disruption via Caprylic Acid & Oregano oil carvacrol*
- Fungal/Candida co-colonisation support via Caprylic Acid & Oregano oil*
- Comprehensive botanical antimicrobial SIBO protocol support*
Quality you can verify
Every batch of SIBOtic™ is manufactured in a GMP-certified facility, 100% vegetarian, non-GMO, and third-party tested for purity and potency. Developed exclusively by Dr. Mona Morstein ND.
180 vegetarian capsules per bottle (30 servings).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Warnings
WARNING: If you are pregnant or breastfeeding, do not use this product. SIBOtic™ is a high-dose antimicrobial formula intended for use under healthcare provider guidance as part of a SIBO protocol — it is not intended for casual daily use or self-treatment without diagnosis. If you are taking medications — particularly blood thinners, diabetes medications, or any prescription drugs — consult your healthcare provider before use. Discontinue if GI symptoms worsen.
