GLP-1 (glucagon-like peptide-1) has become one of the most talked-about topics in metabolic health — and for good reason. This gut-derived hormone plays a central role in normal blood sugar regulation, appetite signaling, and healthy weight management. While prescription GLP-1 receptor agonists have received enormous attention, there is a growing body of research on natural glp-1 support from compounds that support normal GLP-1 secretion and the metabolic pathways it regulates.*
At Priority One Nutritional Supplements, we have been formulating practitioner-grade metabolic support products for decades. This article explores what the current research says about natural compounds and normal GLP-1 pathway support — and which Priority One formulas are most relevant for individuals focused on metabolic health.*
What is GLP-1 and Why Does It Matter?
GLP-1 is an incretin hormone secreted primarily by L-cells in the small intestine and colon in response to food — particularly fats, proteins, and certain dietary fibers. Once released, GLP-1 performs several important functions:
- Stimulates normal insulin secretion from pancreatic beta cells in a glucose-dependent manner
- Suppresses normal glucagon secretion from pancreatic alpha cells, reducing hepatic glucose output
- Slows normal gastric emptying, reducing postprandial blood glucose peaks
- Acts on the hypothalamus to support normal appetite regulation and satiety signaling
- Supports normal beta cell maintenance and function
The result is a coordinated system that supports normal blood glucose levels after meals, promotes a sense of fullness, and reduces overall caloric intake — all central to healthy weight management and normal metabolic function.*
The Natural GLP-1 Support Compounds with the Strongest Research
1. Berberine — The Most Extensively Studied Natural Metabolic Compound
Berberine is an isoquinoline alkaloid found in plants including Coptis chinensis (Huang Lian), Berberis vulgaris (barberry), and goldenseal. It is arguably the most extensively researched natural compound for metabolic support, with over 2,000 published studies and multiple randomized controlled trials in human subjects.
Berberine supports normal GLP-1 pathway activity through several mechanisms. It activates AMPK — the master metabolic enzyme that also mediates many of GLP-1's downstream effects on glucose metabolism. It supports normal GLP-1 secretion from intestinal L-cells and inhibits dipeptidyl peptidase-4 (DPP-4) — the enzyme that degrades GLP-1 — thereby prolonging active GLP-1 availability. Published clinical research has demonstrated berberine's equivalence to metformin in supporting normal fasting glucose and HbA1c in randomized trials.*
Priority One product:
Diamend™ | Advanced Blood Sugar & Metabolic Support by Dr. Mona Morstein ND | 150 Tablets
$180.00
Diamend™ — Practitioner-Formulated Advanced Metabolic & Blood Sugar Support with Split AM/PM Dosing Diamend™ was developed exclusively by Dr. Mona Morstein, ND — a naturopathic physician with decades of clinical experience specialising in integrative metabolic health and diabetes management, and… read more
2. Chromium — Normal Insulin Receptor Sensitivity
Chromium is an essential trace mineral that plays a specific role in normal insulin receptor signalling. Chromium forms part of the chromodulin complex — which amplifies insulin receptor tyrosine kinase activity, enhancing the downstream insulin signalling cascade that GLP-1 activates.* ChromeMate® — a patented chromium polynicotinate used in several Priority One formulas — provides organic chromium with superior bioavailability to inorganic chromium chloride.*
Priority One products:
Hyper GTF™ | 1,500mg Gymnema 25%, ChromeMate® & Botanical Blood Sugar Support | 90 Vegetarian Capsules
$66.00
Hyper GTF™ — High-Potency Gymnema, ChromeMate® & Comprehensive Botanical Support for Normal Blood Sugar & Metabolic Health Hyper GTF™ is a concentrated, botanical-forward metabolic support formula combining five targeted botanical extracts with ChromeMate® chromium at a very high dose —… read more
Healthy Glucose | Quatrefolic® Active Folate, ChromeMate®, Full B Complex & Gymnema for Metabolic Support | 120 Vegetarian Capsules
$50.60
Healthy Glucose — Comprehensive Metabolic & Normal Blood Sugar Support with Three Patented Branded Ingredients Healthy Glucose is a comprehensive metabolic support formula that combines a full, high-potency B vitamin complex — with active and superior forms throughout — with… read more
3. Gymnema sylvestre — The Sugar Destroyer
Gymnema sylvestre is an Ayurvedic botanical whose Sanskrit name — Gurmar — translates to "destroyer of sugar." Its gymnemic acids temporarily block sweet taste receptors, support normal glucose absorption in the intestine, and support normal pancreatic beta cell function — the cells responsible for insulin synthesis and the GLP-1 downstream insulin response.*
Priority One products: Hyper GTF™ Healthy Glucose.
4. Bergamot Polyphenols — AMPK Activation and Lipid Metabolism
Bergamot (Citrus bergamia) contains a unique polyphenol profile including naringenin, hesperidin, neoeriocitrin, brutieridin, and melitidin — not found in any other citrus species. BergacynFF® — the patented bergamot polyphenol complex in Priority One's Belly Trim™ — has been studied in published clinical research for normal AMPK activation and normal HMG-CoA reductase activity. Since AMPK activation is the central mechanism through which GLP-1 exerts many of its metabolic effects, bergamot provides complementary pathway support.*
Priority One product:
Belly Trim | BergacynFF® Liver Health & Metabolic Support | Vegetarian Capsules
$61.60
Belly Trim — Clinically Studied BergacynFF® for Liver Health, Fat Metabolism & Metabolic Balance Most weight management supplements rely on stimulants, appetite suppressants, or broad-spectrum thermogenic blends. Belly Trim takes a fundamentally different approach — targeting the liver, the body's… read more
5. Green Coffee Chlorogenic Acids — Postprandial Glucose Support
Chlorogenic acids from green (unroasted) coffee beans support normal glucose-6-phosphatase inhibition in the liver, reducing hepatic glucose output and normal postprandial blood glucose peaks — complementing GLP-1's own postprandial glucose management mechanisms. They also support normal AMPK activation and healthy fat metabolism.*
Priority One product: W.L. Energizer™ — featuring Green Coffee Bean Extract 45% chlorogenic acids at 249mg per serving.
6. Vanadyl Sulfate — Insulin Mimetic Trace Mineral
Vanadyl Sulfate supports normal cellular glucose uptake through a direct insulin mimetic mechanism — inhibiting PTP1B (the phosphatase that deactivates insulin receptor signalling) and supporting normal GLUT4 glucose transporter translocation in skeletal muscle. This provides insulin-like metabolic support through a pathway distinct from, but complementary to, the GLP-1 axis.*
Priority One product: Vana Trace™ — 10mg elemental vanadium from Vanadyl Sulfate per capsule.
The Role of Gut Health in Normal GLP-1 Secretion
GLP-1 is secreted by L-cells in the intestinal lining — meaning gut health directly influences normal GLP-1 production capacity. A healthy gut microbiome produces short-chain fatty acids (particularly butyrate and propionate) that directly stimulate L-cell GLP-1 secretion. This is why gut health is an important complementary dimension of GLP-1 pathway nutrition.
Priority One's Tributyrin Advanced — featuring CoreBiome® tributyrin (targeted butyrate delivery), BeautyOLIGO® prebiotic galacto-oligosaccharides, and ImmunoLin® immunoglobulin — supports the intestinal environment where GLP-1 is produced.*
A Practitioner's Perspective
Priority One has worked closely with Dr. Mona Morstein ND — one of North America's leading naturopathic physicians specialising in diabetes and metabolic health — to develop several formulas specifically targeting these metabolic pathways. As with all nutritional supplements, these formulas are designed to support normal physiological function — not to replace medical treatment for diagnosed conditions. Individuals with diabetes or who are using GLP-1 medications should consult their healthcare provider before beginning any supplement protocol.*
Explore Our GLP-1 Support Collection
We have curated our most relevant metabolic support products into a dedicated GLP-1 Support collection — making it easy to find the right formula for your metabolic health goals. Each product is manufactured in a GMP-certified facility, third-party tested for purity and potency, and formulated to practitioner-grade standards.*
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. This article is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before beginning any supplement programme, particularly if you have a diagnosed medical condition or are taking prescription medications.
